Troubleshooting - Pharmaceutical Technology

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PharmTech Europe

Troubleshooting

Seven Steps to Solving Tabletting and Tooling Problems---Step 4: Measure

November 20, 2014

Over the last three weeks, we have been looking at each step and the benefit of adopting the process. This week, we look at Step 4, Measure.

Seven Steps to Solving Tabletting and Tooling Problems---Step 3: Repair

November 14, 2014

Carrying on from our weekly column to help you eliminate a number of tablet manufacturing problems and tablet tooling failures with a simple seven-step tool-care process, we look at the third step, Repair.

Seven Steps to Solving Tabletting and Tooling Problems---Step 2: Assess

November 10, 2014

As the second part of this series, we look at the importance of ?assessing? the punches and dies to check their condition and how this step may help avoid any problems that may occur during tablet manufacture.

Determining Facility Mold Infection

October 2, 2014

Pharmaceutical Technology

The recovery of an occasional mold does not merit any particular concern. On the other hand, evidence of mold proliferation indicative of infection of facilities or equipment must be taken seriously and requires the prompt implementation of corrective and preventive actions.

Solving Tablet-Sticking Problems with I Holland's Predictive Model

September 23, 2014

I Holland, in collaboration with the University of Nottingham and experts from the Laboratory of Biophysics and Surface Analysis, United Kingdom, recently completed a two-year tableting science anti-stick research (TSAR) project, which sought to understand why certain formulations stick to tablet tooling.

Complying with Revised Weighing Guidelines

August 2, 2014

Pharmaceutical Technology

The latest revisions to the USP General Chapters <41> Balances and <1251> Weighing on an Analytical Balance aim to ensure weighing accuracy and eliminate unnecessary overtesting by simplifying previous descriptions and reflecting current state-of-the-art weighing practices.

Multifactor Non-linear Modeling for Accelerated Stability Analysis and Prediction

July 2, 2014

Pharmaceutical Technology

The right approach can provide a clear, statistically defendable method for determining dissolution and accelerated stability.

Understanding the Cleaning Validation Lifecycle

April 16, 2014

Equipment and Processing Report

The cleaning validation lifecycle includes assessment, development, validation, and monitoring.

Defining the Sterile Barrier of Complex Drug Delivery Systems

March 17, 2014

Equipment and Processing Report

New injection-delivery systems with multiple closure points pose challenges for container closure integrity testing.

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