The plaintiffs filed a similar suit last year along with a list of other plaintiffs that included "embryos," and were denied standing. Acting as the only plaintiffs, Drs. Sherley and Deisher appealed that decision and were granted standing earlier this year. Writing the opinion for that appeal, Circuit Judge Ginsburg of the United States District Court for the District of Columbia said that permitting federal funding for ESC research so intensified competition for grants that the plaintiffs "will have to invest more time and resources to craft a successful grant application. That is an actual, here-and-now injury." Judge Ginsburg continues with, "The Doctors will suffer an additional injury whenever a project involving ESCs receives funding that, but for the broadened eligibility in the [federal funding] Guidelines, would have gone to fund a project of theirs."
In all likelihood, the plaintiffs are using the "competition" argument to put an end to a technology they oppose on moral and/or religious grounds. A flyer promoting an April presentation at the Massachusetts Institute of Technology by Dr. Sherley identifies him as an "outspoken critic of human embryonic stem cell research" because it promotes "the destruction of innocent human beings." And the website for AVM Biotechnology, for which Dr. Deisher is listed as "Managing Member and Research and Development Director," advertises its work on "adult and other morally acceptable stem cell therapies" as part of its program to deliver "effective and affordable prolife therapeutics."At the moment, the injunction has been temporally lifted pending further legal action. Nevertheless, the opinion itself, not to mention the on-again, off-again support for ESC research, will undoubtedly have a chilling effect on the future of ESC research in particular, but may also have implications for grant funding in general.
By virtue of this decision, the courts seem to be setting a precedent for any researcher in any field to quash competition and improve their own chances of being funded.
It is discouraging to think we will be perpetually stuck in an argument over ESC research, and it would behoove us to have a national discussion to decide once and for all whether we'll fund the research. It is disgraceful that a specious argument intended to stifle one field of scientific inquiry could potentially stymie any legitimate scientific pursuit, and it defies reason that our legal system could defend such an argument and fail to recognize the broader consequences.
Science is a competition of ideas, with newer ones supplanting the old. Public funds to support research are limited, and our system—although not perfect—is meant to reward the best ideas with the most funding. Hopefully, the courts will permanently reverse this decision. Hopefully, too, we'll find a better way to negotiate the difficult moral issues inevitably raised by our scientific advancements without threatening the entire system that generates them.
Michelle Hoffman is editor-in-chief of Pharmaceutical Technology.
Comment from Reader
Dear Ms. Hoffman,
After reading your "From the Editor" article in the October 2010 issue titled "This Again?" it's clear that the editor-in-chief of a major pharmaceutical publication such as this has ventured off of science and into the political world without knowing the facts. To make the statement that "in all likelihood" the plaintiffs are using the competition argument when they really have moral and/or religious objections to embryonic stem cell research is speculative at best and exposes your position. It is very possible and likely that they do have moral objections, but to say that their competition argument is unfounded shows that you don't understand how competitive it is for funding. Funding dollars are not unlimited and to blindly head down a path that has shown absolutely no success in any area of treatment is irresponsible and foolish. Stem cell therapy has been tremendous from sources that make sense, those that are not a risk of rejection and tumor growth. To starve this area of funding and put it toward ESC slows down the rate at which we can legitimately help people who are hurting and dying while we play politics with an unfounded field. Don't you get it that ESC is being pushed not for real science but for politics and to devalue human life at all stages. You cannot use ESC's without cloning someone and quite frankly, President Bush's original funding limit forced our scientists to find an ethical way to generate ESC's which has been done by inducing skin cells into pluripotent cells. These cells have not shown rejection issues like ESC's and have shown promise in therapies. Finally, your statements put women at risk in search of eggs that scientists will need for research. College students, poor women, lured by dollars, will be put through an extremely dangerous procedure in the name of science when it is absolutely unnecessary. Please look into this topic closer and I think you will recognize that we are fortunate so many people are objecting to this research for legitimate reasons.
Sincerely, Doug Lugge Millstadt, IL
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