Analytical Method Development

Apr 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Eventual change in the dissolution characteristics of some dosage forms, which is ascribed to cross-linking of gelatin, continues to present challenges to drug manufacturers. The authors discuss the causes, mechanisms, and solutions to the problem.
Mar 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
This article presents the findings of PhRMA's annual workshop, held in September 2000, that convened to draft an acceptable analytical practice that would clarify the essential elements of a complete and compliant transfer.
Mar 01, 2002
Pharmaceutical Technology
This study investigated the effectiveness of the direct extraction of tablets and shaking time on the disintegration of tablets, solubilization, and recovery of ibuprofen from tablets of various formulations, strengths, and spiked placebo.
Sep 02, 2001
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Because drug delivery at a zero-order rate provides uniform concentration of a drug for absorption, this study attempts to identify a simple mathematical method to quantitatively express the deviation from zero-order kinetics.
Jul 01, 2001
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Appropriate sampling procedures, proper preparation, and correct instrumental parameters may yield differing, but correct, results.
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