Peer-Review Research

Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
In this topical review, the authors discuss the rationale behind microstructural requirements for biopharmaceutical equipment and problems that may be encountered during the fabrication of high-performance corrosion-resistant equipment.
Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate its characteristics to improve bioavailability, stability, manufacturability, and patient compliance.
Mar 02, 2008
Pharmaceutical Technology
Using a handheld Raman spectrometer, the authors developed methods for 28 commonly used excipients and active ingredients.
Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Mannitol is the most commonly used bulking agent in freeze-drying formulation design. The benefit of using mannitol is that it crystallizes during freezing and permits drying processes at higher product temperatures, and thus with higher sublimation rates relative to purely amorphous systems (1). Mannitol, however, is known to form different crystalline modifications which compromises reproducibility of product characteristics and storage stability due to phase transformations (2, 3).
Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
There are significant differences between the United States and European Union requirements for the annual review of records related to the manufacturing and control for pharmaceutical products and active pharmaceutical ingredients.
Feb 02, 2008
Pharmaceutical Technology
FDA is modernizing and streamlining current good manufacturing practices. The author examines FDA's evolving approach to quality systems and how a manufacturer can implement a quality system framework.
Jan 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Natural gums and mucilage are biocompatible, cheap, readily available, and represent a potential source of excipients. The authors examine the functionality of mucilage extracted from the leaves of Hibiscus rosa-sinensis Linn as an excipient in a sustained-release tablet formulation.
Jan 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.
Dec 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors analyzed the effects of complexation as well as the levels of ammonium bicarbonate and crospovidone on tablet wetting time (WT), disintegration time (DT), and percent dissolution efficiency at 60 min (%DE60).
Dec 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Various manufacturing techniques can improve a drug's solubility, thus increasing its bioavailability. The authors examined whether melt granulation can enhance drug solubility using meloxicam as the drug substance and myrj-52 as the binder.
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