Peer-Review Research

Mar 02, 2008
Pharmaceutical Technology
Using a handheld Raman spectrometer, the authors developed methods for 28 commonly used excipients and active ingredients.
Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Mannitol is the most commonly used bulking agent in freeze-drying formulation design. The benefit of using mannitol is that it crystallizes during freezing and permits drying processes at higher product temperatures, and thus with higher sublimation rates relative to purely amorphous systems (1). Mannitol, however, is known to form different crystalline modifications which compromises reproducibility of product characteristics and storage stability due to phase transformations (2, 3).
Mar 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
There are significant differences between the United States and European Union requirements for the annual review of records related to the manufacturing and control for pharmaceutical products and active pharmaceutical ingredients.
Feb 02, 2008
Pharmaceutical Technology
FDA is modernizing and streamlining current good manufacturing practices. The author examines FDA's evolving approach to quality systems and how a manufacturer can implement a quality system framework.
Jan 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Natural gums and mucilage are biocompatible, cheap, readily available, and represent a potential source of excipients. The authors examine the functionality of mucilage extracted from the leaves of Hibiscus rosa-sinensis Linn as an excipient in a sustained-release tablet formulation.
Jan 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors propose extending initial solvent screening for a single-solvent system to the cocktail solvent screening of binary and ternary solvent mixtures.
Dec 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors analyzed the effects of complexation as well as the levels of ammonium bicarbonate and crospovidone on tablet wetting time (WT), disintegration time (DT), and percent dissolution efficiency at 60 min (%DE60).
Dec 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Various manufacturing techniques can improve a drug's solubility, thus increasing its bioavailability. The authors examined whether melt granulation can enhance drug solubility using meloxicam as the drug substance and myrj-52 as the binder.
Oct 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Through consideration of the ionic equilibria of acids and bases, one may readily calculate the formation constant of a salt species solely on the basis of knowledge of the pKA value of the acid and the pKB value of the base.
Oct 02, 2007
Pharmaceutical Technology
By Pharmaceutical Technology Editors
To monitor and control processes or products, analytical methodology must be fit for purpose. An approach to apply quality by design principles to the design and evaluation of analytical methods has therefore been developed to meet these needs.

This article features a downloadable template on which to conduct a failure mode effect analysis (FMEA).
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