Peer-Review Research

Jan 02, 2015
Pharmaceutical Technology
Tocophersolan or TPGS was developed 60 years ago as a water-soluble form of vitamin E. The author gives an overview of TPGS, including its interesting properties, examples found in the literature, and a brief summary of the regulatory status and marketed formulations.
Dec 02, 2014
Pharmaceutical Technology
In anticipation of this mandatory switch from Oxyfume 2000 to 100% EtO for BI testing, comparison studies were performed to determine if the switch from Oxyfume 2000 to 100% EtO would have any impact on BI resistance label claims.
Nov 02, 2014
Pharmaceutical Technology
By Pharmaceutical Technology Editors
This review highlights relevant physicochemical drug properties and formulation design considerations critical to quality and performance of the sublingual tablets.
Oct 02, 2014
Pharmaceutical Technology
Calculate a risk-based guard band associated with reportable values derived from knowledge of the analytical procedure capability.
Oct 02, 2014
Pharmaceutical Technology
Review challenges in the use of normality testing situations and recommendations on how to assess data distributions in the pharmaceutical development manufacturing environment.
Sep 02, 2014
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Febuxostat is a novel, non-purine, selective inhibitor of xanthine oxidase for hyperuricemia in patients with gout. It is the first promising substitute for allopurinol in 40 years. Various synthetic routes to febuxostat, as well as polymorphic forms and impurities of the drug, are reported in the literature. The authors have also identified several impurities that result from the synthesis of febuxostat. This article describes the identification and control of all isomeric, carryover, and byproduct impurities of febuxostat and its intermediates.
Aug 02, 2014
Pharmaceutical Technology
A techno-economic profiling method supports pharmaceutical process development by helping identify the best manufacturing approach.
Jul 02, 2014
Pharmaceutical Technology
The authors look at the cleanability of pharmaceutical soils from a variety of materials of construction to determine the relative ease of cleaning and explore potential grouping strategies as part of a comprehensive cleaning validation program.
May 02, 2014
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Zero-order release of a freely water-soluble active drug can be obtained using release-controlling polymers.
Apr 02, 2014
Pharmaceutical Technology
By Pharmaceutical Technology Editors
A new process analytical technology based on impedance spectroscopy has potential applications for characterizing product attributes during the freeze-drying process.
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