Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Application of Quality by Design to Viral Safety

October 1, 2014

A quality-by-design approach that defines potential viral contaminants of source materials can be used to achieve viral clearance.

Challenges of Protein Aggregation during Purification

September 1, 2014

Careful selection of downstream processing conditions is a must.

A Sampling of New Tools for Downstream Processing

June 1, 2014

Industry suppliers describe new technologies to facilitate downstream processing.

Biopharma Moves to Integrated, Single-Use, Downstream Processing

June 1, 2014

Suppliers see challenges to the adoption of single-use technologies for downstream processing as opportunities.

Raw Material Variability

April 1, 2014

The biopharmaceutical industry is developing a new approach to controlling variability in raw materials.

Single-Use Technology for Syringe Filling

March 1, 2014

A novel approach to sterile drug product manufacturing that uses a single-use assembly in a multi-product final filling suite with isolator technology offers benefits of efficiency and flexibility.

Single-Use Technology in Downstream Processing

March 1, 2014

Experts discuss the advances in single-use technology for downstream bioprocessing applications.

Predicting Lyophilization Performance

March 1, 2014

Researchers are using current understanding of the lyophilization process to predict performance on many levels during both process development and manufacturing.

Tackling the Challenge of Higher-Order Structure Determination

February 1, 2014

Advances in instrumentation, software, and methodologies provide more information than ever on the higher-order structure of proteins.

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