Scale Up & Tech Transfer - BioPharm International

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Scale Up & Tech Transfer

Advances in Linker Technology

March 1, 2014

The targeted delivery of cytotoxic drugs using antibody drug conjugates would not be possible without effective linkers to connect and then release the key chemical and biological materials.

Platform Technology for Developing Purification Processes

March 2, 2009

The future of therapeutic MAbs lies in the development of economically feasible downstream processes.

Economic Drivers and Trade-Offs in Antibody Purification Processes

March 2, 2009

The future of therapeutic MAbs lies in the development of economically feasible downstream processes.

Advances in Non-Protein A Purification Processes for Human Monoclonal Antibodies

March 2, 2009

In three non-affinity purification processes based on cation exchange capture with high binding capacity, applying a host cell protein exclusion strategy enabled robust scale up and better economics.

Purification Strategies to Process 5 g/L Titers of Monoclonal Antibodies

March 2, 2009

Altering the order of operations, using new resins, and increasing dynamic binding capacity can obviate the need for major facilty changes.

A Purification Platform for the Production of MAbs from Fermenters with Titers of 5 g/L and Beyond

March 2, 2009

New techniques can greatly improve the MAb purification process.

The Development and Application of a Monoclonal Antibody Purification Platform

March 2, 2009

A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies.

Considerations for Scaling-up Depth Filtration of Harvested Cell Culture Fluid

March 1, 2009

Data on the performance and variability of different formats.

Chromatography Optimization Strategy

March 1, 2009

Robust packing procedures can improve process performance and increase resin lifetime.

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