Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Downstream Disposables: The Missing Link in the Disposables Chain

August 1, 2010

Although single-use systems are widely used in upstream unit operations, their acceptance in downstream processes has been slow.

Meningitis Vaccine Purification: Quality Control of Ultrafiltration Membrane Porosity

August 1, 2010

How to balance porosity, plugging, and lot-to-lot variability in filters.

Large-Scale Freezing of Biologics: Understanding Protein and Solute Concentration Changes in a Cryovessel—Part 2

July 1, 2010

Large-Scale Freezing of Biologics: Understanding Protein and Solute Concentration Changes in a Cryovessel—Part I

June 1, 2010

Will Protein A Be the Long-Term Solution for Your Purification Needs?

June 1, 2010

Biomanufacturers and vendors are now exploring more cost-effective purification technologies.

Pandemic Response: Progress and Challenges

May 1, 2010

We all know that experience is the best teacher. With H1N1, we have a great opportunity to learn important lessons.

Designing in Quality: Approaches to Defining the Design Space for a Monoclonal Antibody Process

May 1, 2010

How to use risk assessment strategies to integrate operations.

A Study of Leachables for Biopharmaceutical Formulations Stored in Rubber-Stoppered Glass Vials

April 1, 2010

A systematic approach facilitates formulation component selection.

Developing a MAb Aggregate Removal Step by High Throughput Process Development

April 1, 2010

HTPD allows rapid screening of chromatographic parameters.

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