Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Design Space Development for Lyophilization Using DOE and Process Modeling

September 1, 2010

Develop a relevant design space without full factorial DoE.

Technical and Economic Benefits of Membrane Chromatography During Polishing Steps

August 1, 2010

An analysis of flow rate, load density, viral clearance, and cost.

Downstream Disposables: The Missing Link in the Disposables Chain

August 1, 2010

Although single-use systems are widely used in upstream unit operations, their acceptance in downstream processes has been slow.

Meningitis Vaccine Purification: Quality Control of Ultrafiltration Membrane Porosity

August 1, 2010

How to balance porosity, plugging, and lot-to-lot variability in filters.

Large-Scale Freezing of Biologics: Understanding Protein and Solute Concentration Changes in a Cryovessel—Part 2

July 1, 2010

Will Protein A Be the Long-Term Solution for Your Purification Needs?

June 1, 2010

Biomanufacturers and vendors are now exploring more cost-effective purification technologies.

Large-Scale Freezing of Biologics: Understanding Protein and Solute Concentration Changes in a Cryovessel—Part I

June 1, 2010

Designing in Quality: Approaches to Defining the Design Space for a Monoclonal Antibody Process

May 1, 2010

How to use risk assessment strategies to integrate operations.

Pandemic Response: Progress and Challenges

May 1, 2010

We all know that experience is the best teacher. With H1N1, we have a great opportunity to learn important lessons.

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