Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Mixed-Mode Chromatography in Downstream Process Development

March 2, 2010

Salt-tolerant adsorption and unique selectivity are the major advantages of mixed-mode materials over single-mode resins.

The Time Value of Information in Designing Downstream Purification Processes

March 2, 2010

To speed up the downstream process, you must get the right data, in the right amount, at the right time. Here's how.

PEG Precipitation: A Powerful Tool for Monoclonal Antibody Purification

March 2, 2010

This alternative purification method to chromatography is readily scalable and fits a fully disposable downstream process.

Advances in Monoclonal Antibody Purification

March 2, 2010

New technologies and adaptations of existing technologies can improve platform processes.

Downstream Processing: Promising Technologies are on the Horizon

March 1, 2010

The new technologies being developed to improve downstream systems go beyond traditional chromatography.

Characterizing the Formulation Design Space

March 1, 2010

Design of experiments is a valuable tool for identifying aspects of a formulation that are critical to product quality.

The Purification of Plasmid DNA for Clinical Trials Using Membrane Chromatography

February 1, 2010

Membrane chromatography ensures purity at high flow rates.

Influenza Vaccine Enhancement with Immunomodulating Peptide Thymosin Alpha 1

January 2, 2010

Clinical studies have shown that treatment with thymosin alpha 1 increases response to vaccination.

Advancing Adjuvants and Vaccine Delivery Systems for Better Vaccination Strategies

January 2, 2010

This article presents ongoing research at VIDO-InterVac for the development of safer and more effective adjuvants. These include adjuvants that stimulate innate immunity in the body and combination adjuvants.

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