Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

2014 Manufacturing Trends and Outlook

January 1, 2014

Single-use systems and other technologies drive process efficiencies, but there is room for improvement.

Progress in the Prediction of Protein Aggregation

January 1, 2014

Techniques to enable the design and formulation of stable, protein-based therapeutics.

Comparing Protein A Resins for Monoclonal Antibody Purification

December 1, 2013

A prototype Protein A resin is evaluated for purification performance, reusability, and cost performance.

MFI for Particle Characterization of Biopharmaceuticals Today

November 26, 2013

Micro-flow imaging (MFI) is a sensitive, simple and automated method for the routine analysis of sub-visible particles and translucent protein aggregates. This technology provides particle size, count and morphology. Morphology provides the ability to discriminate a wide variety of particle types allowing you to monitor the change in both protein aggregates and other particles over time. This article reviews the application of MFI for monitoring protein aggregates and sub-visible particles in biopharmaceuticals.

Evolution of the Monoclonal Antibody Purification Platform

November 1, 2013

The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics.

Disposable Applications in Demand by Biopharma

November 1, 2013

Data from BioPlan Associates' 10th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production suggest that the interest in disposable devices has begun to extend to biopharma operations beyond basic single-use bags and connectors.

Identification and Quantification of Trace-Level Protein Impurities

September 1, 2013

A simple, sensitive, and universal platform for identification and quantification of trace-level protein impurities in biotherapeutics is described.

Trends in Downstream Bioprocessing

September 1, 2013

While the severity of capacity problems related to downstream processing appears to have eased, it continues to be a problem and chromatography columns are the most frequent culprits.

The Future of Downstream Processing-2013

August 2, 2013

As constant scale up grows out of favor in the biopharmaceutical industry, new—and old—approaches are required. The author reviews the state of downstream processing and considers potential solutions, including the streamlining of full processes and borrowed technologies

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