Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Tackling the Challenge of Higher-Order Structure Determination

February 1, 2014

Advances in instrumentation, software, and methodologies provide more information than ever on the higher-order structure of proteins.

Advances in UPLC Techniques and Column Chemistry Aid the Confirmation of Biosimilarity

February 1, 2014

Automated sample handling, advanced glycan analysis and specially designed columns are helping biosimilar manufacturers speed up confirmation of the biosimilarity of their products.

2014 Manufacturing Trends and Outlook

January 1, 2014

Single-use systems and other technologies drive process efficiencies, but there is room for improvement.

Progress in the Prediction of Protein Aggregation

January 1, 2014

Techniques to enable the design and formulation of stable, protein-based therapeutics.

Comparing Protein A Resins for Monoclonal Antibody Purification

December 1, 2013

A prototype Protein A resin is evaluated for purification performance, reusability, and cost performance.

MFI for Particle Characterization of Biopharmaceuticals Today

November 26, 2013

Micro-flow imaging (MFI) is a sensitive, simple and automated method for the routine analysis of sub-visible particles and translucent protein aggregates. This technology provides particle size, count and morphology. Morphology provides the ability to discriminate a wide variety of particle types allowing you to monitor the change in both protein aggregates and other particles over time. This article reviews the application of MFI for monitoring protein aggregates and sub-visible particles in biopharmaceuticals.

Disposable Applications in Demand by Biopharma

November 1, 2013

Data from BioPlan Associates' 10th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production suggest that the interest in disposable devices has begun to extend to biopharma operations beyond basic single-use bags and connectors.

Evolution of the Monoclonal Antibody Purification Platform

November 1, 2013

The authors discuss the evolution of the purification platform for manufacturing of mAb therapeutics.

Identification and Quantification of Trace-Level Protein Impurities

September 1, 2013

A simple, sensitive, and universal platform for identification and quantification of trace-level protein impurities in biotherapeutics is described.

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