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Scalability of the Mobius CellReady Single-use Bioreactor Systems

April 2, 2013

Review the process-design space and scalability of a single-use, stirred-tank bioreactor.

Custom-Cell Products: Diversified In Vitro Models

April 1, 2013

The author outlines the need for custom-cell products.

Translating Stem Cells From Laboratory to Clinic

April 1, 2013

Ontario-area scientists discuss approaches to development of stem-cell therapies.

Analytical Method Lifecycle: A Roadmap for Biopharmaceutical Development

April 1, 2013

The authors propose a roadmap for analytical lifecycle development.

Increasing Lyophilization Productivity, Flexibility, and Reliability Using Liquid Nitrogen Refrigeration–Part 1 of 2

November 1, 2007

Protein Therapeutics and the Regulation of Quality: A Brief History

October 1, 2007

Regulatory agencies have evolved along with the biotechnology industry to define quality standards.

Plasmid DNA–Based Vaccines: Combating Infectious Diseases

August 2, 2007

Like the egg-based vaccine production process, producing a vaccine under cGMP conditions using mammalian cells can be a lengthy process, taking a minimum of six to 12 months.

New-Age Vaccine Adjuvants: Friend or Foe?

August 2, 2007

Adjuvant-caused vaccine reactions are one of the most important barriers to better acceptance of routine prophylactic vaccination.

The Adjuvant Patch: A Universal Dose Sparing Approach for Pandemic and Conventional Vaccines

August 2, 2007

In animal studies, we have demonstrated that the dose of an injected H5N1 vaccine candidate can be significantly reduced by using a skin patch containing E. coli heat-labile enterotoxin (LT) applied over the injection site. LT-activated epidermal Langerhans cells migrate to the nearby draining lymph node and enhance the immune response to the injected antigen. A dry patch formulation has been optimized as a dose sparing strategy for pandemic flu and other vaccines. Iomai Corporation has developed a proprietary stabilizing formulation for the patch that allows use and storage at ambient temperature. The patch withstands temperature extremes during shipment, and is suitable for stockpiling.

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