Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

A Renaissance in Biomanufacturing: The Art of Purification

August 2, 2013

The industry needs to embrace innovation to improve the efficiency and robustness of biopharmaceutical purification without driving up the cost of goods.

The Future of Downstream Processing-2013

August 2, 2013

As constant scale up grows out of favor in the biopharmaceutical industry, new—and old—approaches are required. The author reviews the state of downstream processing and considers potential solutions, including the streamlining of full processes and borrowed technologies

Clearing Viral Concerns in Animal-Derived Biomaterials

August 1, 2013

Viruses in animal-derived starting materials could contaminate biopharmaceutical final product. A rigorous testing strategy and removal methods are reviewed.

Applying Continuous-Flow Pasteurization and Sterilization Processes

August 1, 2013

The author discusses HTST pasteurization and UHT sterilization.

Focusing on Quality for Parenteral Drug Manufacturing

July 23, 2013

Susan Schniepp, vice-president of quality and regulatory affairs at Allergy Laboratories and co-chair of the program planning committee for the 2013 PDA/FDA Joint Regulatory Conference, discusses quality systems and related considerations in parenteral drug manufacturing.

QbD and PAT in Upstream and Downstream Processing

July 1, 2013

Industry experts discuss the implementation of QbD and PAT tools in biopharmaceutical manufacturing.

Aggregation of Monoclonal Antibody Products: Formation and Removal

March 1, 2013

Aggregate formation is influenced by multiple aspects of the bioproduction process but can be mitigated by good process design and control.

Polishing Complex Therapeutic Proteins

January 1, 2013

A new downstream purification platform using a salt-tolerant membrane adsorber.

The Future of Biopharma

January 1, 2013

What the industry's future holds and what needs to be done to get there.

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