Whitepapers - BioPharm International

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Whitepapers

CONFIDENCE IN BIOLOGICS FORMULATION DESIGN

September 24, 2013

To ensure a long product shelf-life for biopharmaceutical drug products, a stable storage environment is critical. We describe the use of various biophysical techniques as formulation screening tools, to elucidate protein conformation/dynamics.

On October 7, 2013, THE FUTURE SEPARATES FROM THE PAST

September 24, 2013

Imagine a lab where all analytical chemists can generate high-quality mass spectral data. On their own. Within their existing workflow. Across every sample. Without training. A lab where uncertainty about compounds is replaced by fast, efficient validation and the confidence that comes with crossing the LC/MS divide like never before. Now imagine all this happening at the push of a button. This is SEPARATING BEYOND QUESTION

Precise Determination of Protein Molecular Weight

September 24, 2013

This Application Note shows the determination of molecular weight, size, and relative concentration of protein samples after SEC with the Agilent 1260 Infinity Bio-inert Quaternary LC System with Multi-Detector GPC/SEC.

Development of Robust Charge Heterogeneity Assays using DOE

August 27, 2013

Develop robust charge heterogeneity assays using Design of Experiment (DOE). Utilizing imaged cIEF and DOE provides efficient and rapid method development and reduces assay failure. This application note provides a step-by-step process for the successful application of DOE tools with the iCE3.

Shimadzu - Cookie Cutter Proteolysis: Achieving Reproducible, Efficient Digestions for Proteomic Workflows

August 13, 2013

Shimadzu - Cookie Cutter Proteolysis: Achieving Reproducible, Efficient Digestions for Proteomic Workflows

Efficient Material Identification Using Handheld Raman

July 30, 2013

Innovations in instrument miniaturization have resulted in long-wavelength dispersive 1064 nm handheld Raman analyzers. This technology enables stronger quality programs by providing lab-quality material analysis throughout the pharmaceutical production process.

CSH Technology Improves Peptide Separations

July 30, 2013

Having to compromise between a reversed-phase eluent for sharp, symmetrical peaks and one to minimize reduction of MS signal? Waters CSH130 columns offer outstanding peak capacities in peptides and small proteins separations using either 0.1% FA- or 0.1% TFA-containing eluents. They provide excellent mass loading of complex peptides and are QC-tested with a cytochrome c tryptic digest to help ensure consistent results.

Metacomplex Formation & Binding Affinity of Multivalent Binding Partners

July 30, 2013

Metacomplex Formation & Binding Affinity of Multivalent Binding Partners

Novel pH Gradient Separation Platform for Monoclonal Antibody Charge Variant Analysis

July 30, 2013

A novel pH gradient method for cation-exchange chromatography is discussed. Linear pH gradient was achieved using a multi-component buffer system containing multiple zwitterionic buffer species with pI values from 6 to 10.

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