Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Aggregation of Monoclonal Antibody Products: Formation and Removal

March 1, 2013

Aggregate formation is influenced by multiple aspects of the bioproduction process but can be mitigated by good process design and control.

Polishing Complex Therapeutic Proteins

January 1, 2013

A new downstream purification platform using a salt-tolerant membrane adsorber.

The Future of Biopharma

January 1, 2013

What the industry's future holds and what needs to be done to get there.

A New Scale-Down Membrane Adsorber Device for Process Development and Validation

December 1, 2012

The authors describe the development of an ultra scale-down anion exchange membrane adsorber, and demonstrate scalability to larger-scale devices.

Closures for Pharmaceutical Preparations: A Review of Design and Test Considerations

December 1, 2012

The author examines the use of closures for products intended for injection.

The Challenges of Adopting Single-Use Technology

November 2, 2012

Insights on single-use systems implementation and exploitation in biopharmaceutical manufacturing and processing, based on a QbD approach.

Upstream, Downstream Processing in Motion

November 2, 2012

GE Healthcare Life Sciences' ReadyToProcess platform aims to streamline bioprocessing.

It's an Election Year.... Are You Making the Best Choices in Single-Use Tubing

November 1, 2012

The author considers the types of tubing available to the industry and how to make an informed selection.

EU Sets Guidelines for Biosimilar mAbs

November 1, 2012

The European Medicines Agency has added granularity to its biosimilars approval pathway by releasing a guideline on mAbs.

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