Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

The Future of Downstream Processing

September 1, 2011

The author reviews the state of downstream processing, including a look at the streamlining of full processes and borrowed technologies.

Organizational Structures of Process Development and Manufacturing Support

September 1, 2011

How to strike a balance between site autonomy and global coordination.

Technologies for Downstream Processing

September 1, 2011

The author describes recent developments to help overcome the downstream-processing bottleneck.

Analysis of PEGylated Protein by Tetra Detection Size Exclusion Chromatography

August 2, 2011

Reliably detecting low amounts of high molecular weight impurities during process development and characterization of biopharmaceutical products.

Top 1000 Global Biomanufacturing Facilities

August 1, 2011

Insights from real-time ranking of global biomanufacturing capabilities.

Nontuberculosis Mycobacterium Contamination of a Mammalian Cell Bioreactor Process

June 1, 2011

The authors present a case study identifying a contaminant.

Considerations in Identification and Qualification of Spectrophotometer Equipment for Microbial Fermentations

May 1, 2011

The authors outline qualification procedures for a process-critical piece of equipment.

Outsourcing Lean Quality Manufacturing

May 1, 2011

Rapid microbial screening provided by contract laboratories can save companies time and money.

Benefits of a Revised Approach to Anion Exchange Flow-Through Polish Chromatography

April 2, 2011

A high-performance anion exchange resin performs well compared with membranes. In addition, the resin offers greater flexibility and cost savings.

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