Articles on chromatography, filtration, scale-up for proteins, MAbs, vaccines - BioPharm International

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Downstream Processing
The separation and purification steps of biotech processing, including chromatography and filtration. Vaccine and monoclonal antibody (MAb) manufacturing are also found here.

Nontuberculosis Mycobacterium Contamination of a Mammalian Cell Bioreactor Process

June 1, 2011

The authors present a case study identifying a contaminant.

Considerations in Identification and Qualification of Spectrophotometer Equipment for Microbial Fermentations

May 1, 2011

The authors outline qualification procedures for a process-critical piece of equipment.

Outsourcing Lean Quality Manufacturing

May 1, 2011

Rapid microbial screening provided by contract laboratories can save companies time and money.

Innovation and the Art of Downstream Processing

April 2, 2011

This summary provides an introduction to our special issue on Separation and Purification.

Benefits of a Revised Approach to Anion Exchange Flow-Through Polish Chromatography

April 2, 2011

A high-performance anion exchange resin performs well compared with membranes. In addition, the resin offers greater flexibility and cost savings.

Meningitis Vaccine Manufacturing: Fermentation Harvest Procedures Affect Purification

April 2, 2011

Careful analysis of an unusual precipitate identifies defects.

Addressing the Challenges in Downstream Processing Today and Tomorrow

April 2, 2011

Newer classes of biotherapies will require innovations in processing technology.

New Binary Gas Integrity Test Improves Membrane Quality Assurance

April 1, 2011

The authors developed a test for defects in filter membranes.

Systematic Approaches to Develop Chemically Defined Cell Culture Feed Media

November 1, 2010

Making chemically defined media work.

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