Articles by Scott Mack - BioPharm International

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Articles by Scott Mack

Scott Mack


Articles
10 Minute Charge Heterogeneity Analysis
January 2, 2014

Platform methods, high resolution and ease of use have made the iCE system the gold standard for protein charge heterogeneity characterization for biopharmaceuticals. At 15-18 minutes per sample, iCE methods are already fast and simple but now they are even better. In this application note we describe a high throughput 10 minute charge heterogeneity analysis method and performance improvements that provide automated analysis of 100 samples at a time.

10-Minute Charge Heterogeneity Analysis
December 27, 2013

Platform methods, high resolution, and ease of use have made the iCE system the gold standard for protein charge heterogeneity characterization for biopharmaceuticals. At 15-18 minutes per sample, iCE methods are already fast and simple but now they are even better. In this application note we describe a high throughput 10-minute charge heterogeneity analysis method and performance improvements that provide automated analysis of 100 samples at a time.

ProteinSimple - Comparability study of manual and automated particle characterization using MFI
September 24, 2013

Sub-visible particle analysis for biopharmaceuticals can now be automated with Micro-Flow Imaging ( MFI). MFI provides sensitive detection of translucent protein aggregates and other sub-visible particles. This case study from Takeda describes the transfer of a manual method to an automated format.

Development of Robust Charge Heterogeneity Assays using DOE
August 27, 2013

Develop robust charge heterogeneity assays using Design of Experiment (DOE). Utilizing imaged cIEF and DOE provides efficient and rapid method development and reduces assay failure. This application note provides a step-by-step process for the successful application of DOE tools with the iCE3.

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