Articles by Paul Ng, PhD - BioPharm International

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Articles by Paul Ng, PhD

Paul Ng, PhD


Improving Aggregate Removal from Monoclonal Antibody Feed Using High Resolution Cation Exchange Chromatography
August 27, 2013

Nuvia™ HR-S media is a new cation exchanger designed for high resolution of closely related product impurities such as aggregates. It delivers excellent resolution with a final aggregate content of < 0.3% and a high recovery of > 80% from a heterogeneous feed of monoclonal antibody aggregates and monomer. Aggregate content and recovery in the eluate were shown to be a function of the target conductivity measured at the end of collection

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