Articles by Randy Jacinto, PhD - BioPharm International

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Articles by Randy Jacinto, PhD

Randy Jacinto, PhD


Improving Aggregate Removal from Monoclonal Antibody Feed Using High Resolution Cation Exchange Chromatography
May 26, 2014

Nuvia™ HR-S media is a new cation exchanger designed for high resolution of closely related product impurities such as aggregates. It delivers excellent resolution with a final aggregate content of <0.3% and a high recovery of >80% from a heterogeneous feed of monoclonal antibody aggregates and monomer. Aggregate content and recovery in the eluate were shown to be a function of the target conductivity measured at the end of collection.

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