Small-Molecule APIs

Nov 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
IPEC Chairman Dave Schoneker discusses current efforts toward facilitating regulatory reviews of new excipients.
Oct 01, 2008
Pharmaceutical Technology Europe
The potent nature of HPAPIs means there must be careful evaluation of the compound for its level of toxicity when considering manufacture.
Sep 01, 2008
Pharmaceutical Technology Europe
Near-infrared spectroscopy (NIR) is suitable for the analysis of pharmaceutical samples in various solid forms, and can be used for determining chemical properties (e.g., content of drug, water), as well as physical properties (e.g., particle size, tablet hardness).
Jul 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Clear labels for substances that can be used as excipients, APIs, or both are critical to end-product use.
May 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The less complex nature of excipient manufacturers, as compared with API manufactures, carries many benefits.
May 01, 2008
Pharmaceutical Technology Europe
The pharmaceutical industry must address the release of nonbiodegradable APIs into the environment.
Apr 02, 2008
Pharmaceutical Technology
By Pharmaceutical Technology Editors
A changing regulatory environment is on the horizon for excipient suppliers and users.
Dec 01, 2007
Pharmaceutical Technology Europe
Lipid-based drug delivery systems — such as liposomes, micro-and nanoemulsions, self-emulsified drug delivery systems, and solid lipid micro-and nanoparticles — are becoming more popular because lipid materials are easily characterized, contain a high range of well-defined/tolerated surfactant molecules and can be developed for several administration routes.
Nov 01, 2007
Pharmaceutical Technology Europe
The crystalline structure of pharmaceutical solids can sometimes be altered during processing. X-ray powder diffraction and near infrared spectroscopy can be used to determine the amorphous and crystalline content of a model substance. The two techniques' precision, accuracy, detection limit and the speed of analysis are compared.
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