Dosage Forms

Oct 01, 2002
Pharmaceutical Technology Europe
High quality tablet compression tooling is expensive, albeit consumable. With the potential for tooling damage during tablet production, transportation and storage, an acceptable method of cleaning, repairing, validating and storing tooling is required by anyone who manufactures tablets - and the regulatory inspection authorities.
Oct 01, 2002
Pharmaceutical Technology Europe
Using melt extrusion to prepare glass solutions of poorly water-soluble drugs with hydrophilic excipients offers an exciting and advantageous alternative to existing formulation methods such as spray-drying and co-melting. Investigating potential methods to increase water solubility begins early in drug development. Techniques described in this paper show how only a small quantity of drug can be used to determine its suitability for melt extrusion, allowing the method to be considered at the same time as salt screening and particle size reduction work, and could speed up the formulation process.
Jul 01, 2002
Pharmaceutical Technology
Extensive research has been conducted to improve the solubility and permeability of acetazolamide in hopes that a topical formulation for the treatment of glaucoma can be developed.
May 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
A knowledgeable and experienced contract service provider can help in the development and success of an inhalation drug product.
May 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Recent advances in polymer science have resulted in a wide range of commercially available polymers for use in transdermal drug delivery systems.
Mar 01, 2002
Pharmaceutical Technology
Adhesives manufacturers can be involved in the development of transdermal drug delivery products by working with pharmaceutical companies on R&D, materials qualification, manufacturing, and other product development tasks.
Jan 01, 2002
Pharmaceutical Technology
To achieve the maximum performance from a tablet press run, operators must learn to distinguish between machine-related issues and granulation-related issues.
Jan 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors discuss the solubility and adhesive performances of adhesives that incorporate monomers such as hydroxyethyl acrylate or pyrrolidonoethyl acrylate.
Oct 01, 2001
Pharmaceutical Technology
The authors modified a three-layer press to operate a compression-coated tablet process that may offer several advantages over tradditional compression coating operations.
Oct 01, 2001
Pharmaceutical Technology
Tablet manufacturers often overlook critical basic concepts or established practices. The author draws from his own experiences and discusses how solid dosage manufacturers can improve production and product quality by optimizing major unit operations.
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