Excipients

Dec 02, 2003
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The influence of light on the rate of moisture gain was investigated in 36 drug substances and 18 excipients.
Oct 01, 2003
Pharmaceutical Technology Europe
Erythritol is a bulk sweetener polyol that is suitable for a variety of reduced-calorie and sugar-free foods. It has been part of the human diet for thousands of years because of its presence in foods such as fruit, mushrooms and fermentation-derived products including wine, soy sauce and cheese. This article investigates the properties of erythritol and describes how it can be used as a pharmaceutical excipient.
Jun 02, 2003
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The authors investigated the moisture gain of products containing ethambutol that were packaged in strip and blister packs as well as unpackaged formulations.
Mar 02, 2003
Pharmaceutical Technology
By Pharmaceutical Technology Editors
As parenteral drug delivery becomes more complex and sophisticated, excipients that can facilitate drug (or gene) delivery to specific therapeutic targets will be required. An overwhelming majority of these excipients are derived from natural sources.
Mar 01, 2003
Pharmaceutical Technology Europe
The tabletting properties of a new coprocessed excipient for direct compression were compared with a physical mixture of its components (separately and with drugs) and the individual constituents. The compaction properties were also investigated. Results indicated that the new excipient has excellent flow properties and demonstrates enhanced compressibility.
Jan 01, 2003
Pharmaceutical Technology Europe
Medicines and excipients are inseparable, with few exceptions - one cannot exist without the other. The Pharmaceutical Quality Group and other international bodies have developed good manufacturing practice (GMP) standards and guidelines to facilitate the effective supply of excipients. This article discusses the definition and significance of excipients, and highlights the importance of implementing the correct excipient manufacturing controls and standards.
Nov 01, 2002
Pharmaceutical Technology Europe
The aim of this work was to investigate the compactibility, compressibility and drug release behaviour of different fractions of a commercially available ethyl cellulose.
Oct 01, 2002
Pharmaceutical Technology Europe
Using melt extrusion to prepare glass solutions of poorly water-soluble drugs with hydrophilic excipients offers an exciting and advantageous alternative to existing formulation methods such as spray-drying and co-melting. Investigating potential methods to increase water solubility begins early in drug development. Techniques described in this paper show how only a small quantity of drug can be used to determine its suitability for melt extrusion, allowing the method to be considered at the same time as salt screening and particle size reduction work, and could speed up the formulation process.
Oct 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
In this study, the authors investigated the compression behavior of excipients with different molecular weights using the modified Fraser-Suzuki function and correlated the S-parameter of this function with Young's modulus.
Jun 01, 2002
Pharmaceutical Technology
By Pharmaceutical Technology Editors
A global drug master file system may pave the way for faster qualifications of new excipients and the industry's acceptance of their use in drug therapies.
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