Formulation

Apr 02, 2017
Pharmaceutical Technology
Interpretation of calorimetric data is tricky. The author suggests 10 questions that should be asked of any calorimetric method, along with the rationales behind them.
Apr 02, 2017
Pharmaceutical Technology
Design of experiment plays a crucial role in the optimization process of formulation development.
Apr 01, 2017
Pharmaceutical Technology
A case study reviews the reformulation and scale up of high drug load prototype using wet granulation process for a model formulation.
Apr 01, 2017
Pharmaceutical Technology
Solid dispersions based on organic polymers can have stability issues. Inorganic solids, especially those based on silica chemistry, may be suitable alternatives to organic polymers due to their pre-formed pore system, high absorptivity, and commercial availability in pharmaceutical quality. Mesoporous granulated colloidal silicon dioxide has been studied with class II and IV actives of the Biopharmaceutics Classification System for its ability to improve dissolution. Using suitable formulation strategies, the dissolution of these APIs could be significantly increased. The absorption of poorly soluble APIs onto silicon dioxide can, therefore, be considered a viable formulation path to overcome solubility challenges.
Mar 30, 2017
PTSM: Pharmaceutical Technology Sourcing and Management
By Pharmaceutical Technology Editors
The newly installed Harro Hӧfliger encapsulation unit expands Capsugel’s clinical- and commercial-scale capacity for dry powder inhalation projects.
Mar 02, 2017
Pharmaceutical Technology
Capsule filling is a complex process, and the product to be encapsulated must be well developed to ensure mass uniformity.
Mar 02, 2017
Pharmaceutical Technology
The authors discuss the challenges of capsule filling in preclinical and clinical studies.
Mar 02, 2017
Pharmaceutical Technology
This study investigated the stability of solid lactose stored under high temperature and humidity conditions.
Mar 02, 2017
Pharmaceutical Technology
Effective solutions for overcoming the high molecular weight, hydrophilicity, and instability of large biomolecules have yet to be identified.
Feb 02, 2017
Pharmaceutical Technology
More agile techniques are improving the development of multiparticulate drug-delivery systems.
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