Gelatin Capsule Shell Cross-Linking

May 01, 2011
By PharmTech Editors

By Xiling Song, Yong Cui and Minli Xe

Cross-linking in hard gelatin capsule shells is a common cause of slowdown in Tier I dissolution testing; however, direct addition of purified pepsin to the medium, as described in USP , may not always be a solution if the medium contains sodium lauryl sulfate (SLS). The author develops a practical approach to avoid unwanted interaction between pepsin and SLS in dissolution Tier II tests.

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.