Inhibiting the Precipitation of Poorly Water-Soluble Drugs from Labrasol Formulations

May 31, 2011
By PharmTech Editors

By Wei-Guo Dai, Liang C. Dong and Abla A. Creasey

The authors sought to identify a precipitation inhibitor for Labrasol formulations that include poorly water-soluble drugs. Two low solubility compounds were combined with Pluronic F127, polyethylene glycol 400, and N-methyl-2-pyrrolidone. The study results suggested that Pluronic F127 might be a potent inhibitor of drug precipitation for Labrasol formulations.

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.