By Wei-Guo Dai, Liang C. Dong and Abla A. Creasey
The authors sought to identify a precipitation inhibitor for Labrasol formulations that include poorly water-soluble drugs. Two low solubility compounds were combined with Pluronic F127, polyethylene glycol 400, and N-methyl-2-pyrrolidone. The study results suggested that Pluronic F127 might be a potent inhibitor of drug precipitation for Labrasol formulations.
This article was also published in our US sister publication Pharmaceutical Technology and can be read here.