Jeff Driscoll is an associate group leader at PPD GMP Lab, Middleton, WI.

Jeff Driscoll

Sample preparation is a crucial step during particle size analysis, especially when trying to maximize accuracy and precision. A vortex mixer is frequently used its importance may be overlooked.

	If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.

Pharmaceutical Technology's Bio/Pharma Laboratory Best Practices

: Bio/Pharma Laboratory Best Practices 2018

	When referring to this article, please cite it as G. Maj, et al., "The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals," 

Pharmaceutical Technology Bio/Pharma Laboratory Best Practices

Articles

If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can
change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size
distribution.