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In addition, the bioreactor is available with an open-architecture process control that allows personnel to use a turn-key integrated controller or any other preferred controller. The systems also use ATMI’s Integrity TK8 film-polymer vessels. After a manufacturer qualifies the multilayer film for use in a process, it does not need to requalify other Integrity processes or vessels of various sizes.
The SciFlex device is compatible with disposable tubing sets that eliminate the need for cleaning and reduce the potential for cross-contamination. Disposable tubing sets also allow the unit to accommodate flat-sheet and hollow-fiber filters from any manufacturer.
A touch-screen interface allows operators to control the system, including the diafiltration and feed pumps. The touch screen also provides real-time trending, documentation, and connectivity for data-collection applications. The control unit achieves the target flow rate and maintains diafiltration retentate by controlling set points semiautomatically.