By Amelie Desire, Bruno Paillard, Joel Bougaret, Michel Baron and Guy Couarraze

The authors compare three systems of single-screw extrusion (i.e., radial, dome, and axial) using binary formulations (i.e., microcrystalline cellulose, and active material) for their suitability for producing pellets of various formulations and under various spheronization conditions. Pellets were characterized by their size and shape, and by their structural and mechanical properties. The experimental design showed high variation between the three extrusion systems.

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.