Even though they do not create final dosage forms, analytical instruments are a crucial part of any pharmaceutical manufacturing
line. These devices help confirm the identity of ingredients and ensure consistent quality from batch to batch. Regulators
have promoted these instruments' ability to provide companies with greater understanding of their processes. Analytical instruments
also can confirm that other equipment is working properly. This month's products illustrate the ways that analytical devices
help manufacturers. Hiden's system couples a microreactor with a mass spectrometer. FRITSCH's instrument offers high-resolution
analysis of particle size and shape. A filter-integrity tester from Sartorius cleans itself automatically.
Analytical system incorporates two close-coupled modules
Hiden Analytical's (Warrington, UK) CATLAB system combines a microreactor and mass spectrometer with fully integrated control
software. The two close-coupled modules are designed to offer continuous real-time analysis of catalytic activity. The system
also evaluates various reaction components simultaneously and provides overall response times of less than 0.5 s.
CATLAB system Hiden Analytical www.hidenanalytical.com
The system's fully preprogrammable and automated analysis cycles enable users to control ramp rates, temperature range, temperature
dwell periods, gas flows, pulse switching, and the mass spectrometer. More than 4000 processes can be completed in one cycle.
The reactor incorporates a bypass channel so that gas flow may be set up and mixtures prepared independently of the sample
Operators can detach the CATLAB system's mass spectrometer easily for use off-line. The high-sensitivity quadrupole mass spectrometer
has a detection limit of 0.1 to 1 ppm, subject to spectral interference, and takes as many as 1000 measurements/s.
Instrument analyzes particle size and shape
The ANALYSETTE 22 NanoTec instrument from FRITSCH (Idar-Oberstein, Germany) automatically analyzes particle-size distribution
and particle shape. Scientists can move the instrument's measuring cell easily between the Fourier lens and the detector
to achieve high resolution. The instrument analyzes coarse materials best when the measuring cell is far from the detector.
ANALYSETTE 22 NanoTec instrument FRITSCH www.fritsch.de
The instrument provides high-resolution images of small particles when the measuring cell is close to the detector. Through
a small opening at the center of the detector, a second laser beam irradiates the sample from behind, and backward-scattered
light can be captured with full resolution.
Instrument performs many filter-integrity tests
The Sartocheck 4 plus instrument from Sartorius (Goettingen, Germany) performs a battery of filter-integrity tests such as
diffusion, bubble point, diffusion–bubble point, water intrusion, water flow, customer-specific bubble point, customer-specific
diffusion, and multipoint diffusion. The operator can select the test program manually or use a barcode reader to enter data
into test programs. When the operator scans a filter's barcode, the instrument recalls the appropriate test program for that
filter automatically. The tester can connect to a network and exports results as PDF files that can be shared easily with
other data systems.
Sartocheck 4 plus instrument Sartorius www.sartorius.com
In addition, operators can prompt the tester to clean itself automatically in about an hour. Users add cleaning solution into
a separate vessel, and the tester cleans, rinses, and dries its entire pneumatic path. Operators thus do not need to send
the instrument to the manufacturer for cleaning, and this feature reduces downtime and cost.