|Email Newsletters from Pharmaceutical Technology and Pharmaceutical Technology Europe|
News from Europe's pharmaceutical manufacturing industry coupled with upcoming events, and exclusive articles and interviews from industry experts.
Week of July 11, 2011: UPS and Merck Extend Distribution and Logistics Agreement; Merck Serono Makes Two Executive Management Team Appointments; and More.
Bristol-Myers Squibb and Innate Pharma, a biopharmaceutical company, have formed a global agreement for the development and commercialization of IPH2102, an antibody in Phase I development for treating cancer. Under the agreement, Innate Pharma will grant to Bristol-Myers Squibb exclusive worldwide rights to develop, manufacture, and commercialize IPH2102 and related compounds blocking KIR receptors. The agreement covers all potential indications for IPH2102. Innate Pharma will continue to develop IPH2102 in acute myeloid leukemia through to the end of Phase II. Innate Pharma will also provide preclinical support for the development of IPH2102. Bristol-Myers Squibb will fund the development of IPH2102, make an upfront payment of $35 million, and provide additional payments of up to $430 million, depending on the achievement of prespecified milestones during the development and commercialization period, as well as prespecified tiered double-digit royalty payments on worldwide net sales.
Janssen Pharmaceutica, a division of Johnson & Johnson’s (J&J) subsidiary Janssen Pharmaceutical Companies, has completed the divestiture of its animal-health business to Elanco, a division of Eli Lilly. Financial terms of the transaction were not disclosed. Under the transaction, Elanco acquires products, contracts, and related intellectual property and marketing authorizations. The terms of the offer also include that the employees, active in 11 different countries, transfer to Elanco.
In other news, McNeil Consumer Healthcare, a division of J&J’s subsidiary McNeil-PPC, reported on June 28, 2011, that it is recalling at the retail level one product lot (60,912 bottles) of Tylenol, Extra Strength Caplets, 225 count bottles, distributed in the US. The recalled product was manufactured in February 2009. McNeil is taking this action following a small number reports citing the presence of a musty, moldy odor. The uncharacteristic odor has been linked to the presence of trace amounts of a chemical, 2,4,6-tribromoanisole.
UPS and Merck have extended their existing distribution and logistics agreement to include aspects of Merck’s global supply chain around the world. UPS currently manages the distribution, warehousing, and transportation of Merck’s medicines and vaccines in North America.
Mylan has expanded its licensing agreement between Gilead Sciences and Mylan’s Matrix Laboratories. Matrix has licensed the rights to produce and market generic versions of three Gilead HIV/AIDS therapies, pending regulatory approval. The Gilead products, which are currently in late-stage clinical development, include: elvitegravir, an investigational integrase inhibitor; cobicistat, an investigational antiretroviral boosting agent; and the “Quad,” a once-daily, single-tablet combination of four separate Gilead medicines.
The contract development and manufacturing organization Pharmalucence has selected Integrated Project Services to provide architectural design, engineering and construction of its aseptic manufacturing facility in Billerica, Massachusetts. Pharmalucence has initiated the first phase of its construction program to prepare for partial occupancy of the facility in late 2011. All phases of construction will be completed by mid-2012, with implementation of full drug manufacturing by mid-2013.
Pfizer has announced that it is exploring alternatives for its animal-health and nutrition businesses based on a recent business portfolio review to determine the optimal mix of businesses for maximizing shareholder value. The company is considering options that may include, among others, a full or partial separation of each of these businesses from Pfizer through a spinoff, sale, or other transaction. Given the separate and distinct nature of animal health and nutrition, the company may pursue a different alternative for each business.
Sanofi has agreed to divest its dermatology business, Dermik, to Valeant Pharmaceuticals International, a specialty pharmaceutical company for $425 million. Dermik’s portfolio includes therapeutic and aesthetic dermatology brands such as BenzaClin for the treatment of acne, Carac for the treatment of keratoses, and Sculptra, a facial injectable for the treatment of facial wrinkles and folds. Also included in the divestment is Sanofi’s Laval, Canada, site, which includes Dermik’s manufacturing facility. Sanofi’s Canadian affiliate, sanofi-aventis Canada, will maintain its operations in Canada. The deal is subject to customary closing conditions and regulatory approval.
Carbogen Amcis, a contract development and manufacturing organization, has named Mark C. Griffiths as CEO. In his new role, Griffiths will manage the company’s Swiss business and will report to Jay Vyas, managing director of Dishman Pharmaceuticals and Chemicals, Carbogen Amcis’ parent company.
The Department of Science and Technology of New Delhi, India, has awarded $1.5 million for a two-year period to K. Ruckmani, PhD, professor and head of the department of pharmaceutical technology at Anna University of Technology at Tiruchirappalli, India, to establish a national facility on drug development.
Eli Lilly has named its current senior vice-president of global quality, Fionnuala Walsh, to its executive committee. Walsh will report to John Lechleiter, chairman, president, and CEO of Lilly.
Merck Serono, a division of Merck KGaA, has made two appointments to its executive management team. Belén Garijo has been named as chief operating officer, effective Sept. 1, 2011, and Annalisa Jenkins has been named as global head of drug development and medical, effective Sept. 5, 2011.
Smithers Pharma Services, an analytical chemistry and formulation service provider, has appointed Prasad Raje, PhD, as president. Raje will report to Smithers’ group president and CEO Michael Hochschwender. Raje joined the Smithers organization in October 2009, and has served as executive vice-president of Smithers Viscient since February 2011.