PharmTech:
James Ingebrand
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How has the increase in biopharmaceutical development influenced innovation in drug delivery? On an industry level, what are
some key developments and targets for delivering biologic-based drugs?
Ingebrand:
It has to be acknowledged that the challenge of delivering biologic-based drugs has been an important driver of innovation
in the drug delivery technology industry. Unfortunately, many of these technologies have failed to deliver on their initial
promise. We have all seen the bold claims for the oral delivery of proteins and peptides. Inhaled insulin and the like burst
on to the scene, and then faded into obscurity. This was not for lack of effort so, clearly, the technical and market challenges
are great.
The fact that the industry, including 3M Drug Delivery Systems, continues to innovate in this arena speaks to the great need
to offer a real alternative to injections and provide options for improved pharmacokinetic profiles and dose-sparing possibilities.
At 3M Drug Delivery Systems, we believe our Microstructured Transdermal System (MTS) is a practical solution for addressing
many of these issues. Our initial clinical success is turning concept into reality and generating considerable interest for
a range of therapeutic areas, ranging from rheumatoid arthritis to vaccines.
PharmTech:
How do you think personalized medicine will influence drug-delivery technology and methods of delivery?
Ingebrand:
I think we will continue to see personalized medicine expand in scope. We see this manifested in a number of ways, including
the launch of companion diagnostic tests as part of new drug introductions. Peering deeper into the crystal ball, I think
the most interesting future developments for the drug delivery industry will be around "smart dosing" and therapeutic feedback
loops. I can imagine a time when one's Smartphone, loaded with the latest apps, will monitor key physiological parameters
and then either recommend or actually control the delivery of a therapeutic agent. 3M Drug Delivery Systems' hollow microneedle
arrays (hMTS), for example, can provide a platform that could well enable that sort of next-generation technology.
