July 2012 Editor's Picks: Products from Sartorius Stedim Biotech and Waters - Pharmaceutical Technology

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July 2012 Editor's Picks: Products from Sartorius Stedim Biotech and Waters

Equipment and Processing Report

Featured products from Pharmaceutical Technology's monthly newsletter, Equipment & Processing Report

Sartorius Stedim Biotech

Sterilizing-grade filter improves biopharmaceutical manufacturing efficiency

Sartorius Stedim Biotech’s (SSB) Sartopore Platinum sterilizing-grade filter for biopharmaceutical manufacturing improves product yields and filtration performance. The surface of the polyethersulfone filter membrane has been modified using a hydrophilic, thermostable polymer. This surface modification increases wetting properties, which reduces the amount of water for injection needed to wet the cartridge, and minimizes protein binding, which increases product yield. The membrane has been pleated using SSB’s newly developed, proprietary TwinPleat process. The alternating long and short pleats of the membrane increase the filter area of a 10 in. cartridge by more than 60%. At the same time, this geometry ensures that liquids flow through the entire filter area so that the filtration capacity of the cartridge is used to the fullest extent, which improves filtration performance and lower filtration costs. The filter cartridges can be dry-steam sterilized in the forward or the reverse direction without altering the properties of their membrane.  The filters can be used in the entire pH range from 1 to 14.

Mass spectrometers with increased sensitivity reduce laboratory downtime

Waters added its StepWave ion optics technology to its new Xevo G2-S QTof and Xevo G2-S Tof benchtop, time-of-flight mass spectrometers (MS), which makes them up to twenty times more sensitive than earlier-generation instruments.  StepWave ion optics technology transfers ions efficiently while actively filtering out undesirable neutral contaminants. As a result, MS signals are increased and, because critical components in the device stay clean for longer periods of time, quantitative results are more reproducible and laboratories experience less downtime due to routine cleaning and maintenance.  The instruments are designed to work with Waters ACQUITY UltraPerformance LC System and are capable of achieving low detection limits with minimal sample volumes.


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Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
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Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
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