Purification system maintains constant flow rate
SciLog’s (Middleton, WI) mobile SciFlex 150 tangential-flow filtration system is designed for pilot-scale biopurification applications. The system’s separate, independently controlled feed and diafiltration pumps allow for automated maintenance of constant flow rate or pressure during ultra- or diafiltration. Precalibrated in-line sensors provide real-time process data about pressure, temperature, and conductivity, while a balance measures the retentate and permeate in the system.
The SciFlex device is compatible with disposable tubing sets that eliminate the need for cleaning and reduce the potential for cross-contamination. Disposable tubing sets also allow the unit to accommodate flat-sheet and hollow-fiber filters from any manufacturer.
A touch-screen interface allows operators to control the system, including the diafiltration and feed pumps. The touch screen also provides real-time trending, documentation, and connectivity for data-collection applications. The control unit achieves the target flow rate and maintains diafiltration retentate by controlling set points semiautomatically.