Sartorius Stedim Biotech
Membrane binds contaminants at high conductivities
The Sartobind STIC PA membrane from Sartorius Stedim Biotech uses free primary-amino ligands at high density to bind contaminants at high conductivities through ion exchange. Unlike traditional quaternary ammonium membranes, the Sartobind STIC PA membrane does not require the cation ion-exchange pools to be diluted to bind the negatively charged contaminants. This characteristic can help users reduce buffer consumption and buffer-tank costs. The Sartobind membrane also removes host-cell proteins, DNA, viruses, and endotoxins at salt conditions as high as 20 mS/cm.
The series of membranes includes six capsule sizes from 0.08 mL to 1.6 L. All of the membranes are suitable for flow-through polishing, and users can maintain a 4-mm bed height to scale up to larger devices. The membrane-adsorber capsules are plug-and-play devices that can be used like filters. Personnel can discard the materials after a single use, thus reducing validation costs.