Trends in Tablet Tooling - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Trends in Tablet Tooling


Pharmaceutical Technology Europe
Volume 26, Issue 8, pp. 28
PharmTech Europe 25th Anniversary
DSGpro/Getty Images;
Art direction: Dan Ward

Surveying the Landscape of Solid-Dosage Manufacturing

Experts take a look at the journey travelled thus far and where pharmaceutical manufacturing is heading over the next decade.

The past decade has seen rapid advances in tablet tooling technology and the acceptance by tablet manufacturers that tooling is a critical part of the tablet production process. Tooling has traditionally been viewed as a consumable item by tablet manufacturers, but this view has changed in recent years as companies invest more in looking after their tooling assets and focus on obtaining a longer life from their punches and dies through improved maintenance and aftercare practices. Tablet manufacturers accept that tablet tooling can have a beneficial effect on the production of good quality tablets, and we have seen a rapid increase in requests for technical support to this end.

Pharmaceutical Technology Europe
25th Anniversary Issue


Quality by Design—a Fundamental Paradigm Shift in Pharmaceutical Manufacturing

Tableting—a Focus for Continuous Improvement

Continuous Manufacturing—the Future of Pharmaceutical Manufacturing

Advances in Film Coating

Polymers for Solubility Enhancement

A rapid growth area has been that of coating technology. Tool coatings are now seen as an acceptable means of solving production problems, such as sticking and corrosion, resulting in increased product yield while also extending tooling life. They provide for increased tableting efficiency and output, for example, by reducing the requirement for tools to be taken out of production for additional maintenance work.

Tablet and tool design are also areas that have increased in importance as companies are keen to establish a strong brand identity for their tablet products, while at the same time ensuring that the design can function in the rigours of a tablet production environment. Design is also a key tool by which production problems can be overcome and eliminated. These problems may not always be compression-related issues (e.g., picking) but can also be related to downstream processes such as packaging.

The functionality of the tablet press itself has changed over the past decade as presses are more technologically advanced today. Compression speeds have increased dramatically and, therefore, the demands on the performance of the tooling have increased. The new generation of tablet presses require more exacting tooling standards to be met, and the ability to meet exacting specifications and stringent requirements for optimised surface finish have become particularly important.

The adoption of multi-tip tools has also increased as tablet manufacturers strive to be more efficient and increase productivity in a time where financial resources may be constrained. Multi-tip tooling is now recognised and accepted as a credible alternative to purchasing a new tablet press, for example.

Steve Deakin
Steve Deakin

About the Author
Steve Deakin is business development director at I Holland.

ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
25%
Oversee medical treatment of patients in the US.
13%
Provide treatment for patients globally.
10%
All of the above.
43%
No government involvement in patient treatment or drug development.
10%
Jim Miller Outsourcing Outlook Jim MillerCMO Industry Thins Out
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerFluorination Remains Key Challenge in API Synthesis
Marilyn E. Morris Guest EditorialMarilyn E. MorrisBolstering Graduate Education and Research Programs
Jill Wechsler Regulatory Watch Jill Wechsler Biopharma Manufacturers Respond to Ebola Crisis
Sean Milmo European Regulatory WatchSean MilmoHarmonizing Marketing Approval of Generic Drugs in Europe
FDA Reorganization to Promote Drug Quality
FDA Readies Quality Metrics Measures
New FDA Team to Spur Modern Drug Manufacturing
From Generics to Supergenerics
CMOs and the Track-and-Trace Race: Are You Engaged Yet?
Source: Pharmaceutical Technology Europe,
Click here