Method Scouting Solution - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Method Scouting Solution

Since the introduction of UHPLC, strategies for fast method development are being discussed.
A wide variety of columns with different separation properties is available, offering the user a number of columns suited to a specific application. To automate this evaluation step and get quick information about the best column and mobile phase, different strategies have been applied.

The Nexera Method Scouting system has been designed to be used for fast and simple screening of possible combinations of columns and mobile phases. The two pumps in the binary gradient system are therefore equipped with quaternary gradient capabilities for the aqueous and organic solvents supporting solvent blending on each of the pumps. To handle a number of columns, the system has a selection valve which allows a maximum of six columns to be chosen in a scouting process. The photodiode array of MS detectors can be used in combination with the system.

To support the complex and time consuming process of method development and sequence setup, special software is applied on top of the LabSolutions software. A simple user interface allows a fast setup of the method, column selection and adaptation of the gradient profile and analysis time. Global system parameters such as rinse volume and column and solvent database are set once at the beginning, and can be selected afterwards by a tick box.

For data analysis, features of the standard software such as the data browser can be used for a fast and simple overview of the result. A pre-selection is done according to the number of separated peaks. For a more detailed look at the results – a specially designed Agent Report is available.

To offer a complete solution, the Method Scouting can be combined with the dedicated

DryLab® 4 software for Method Optimisation to get a clear picture of method details and optimal separation conditions and the robust space. If a complete method validation should be the result of all investigations, the Validat ® software can be linked to the LabSolutions software and performs the necessary calculations while delivering all results in compliance with the regulations.

For more information please visit

DryLab® 4 is a registered trademark of Molnar Institute of Applied Chromatography
Validat® is a registered trademark of iCD


LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
FindPharma Custom Search

Click here