Pharmaco-Kinesis Corporation Develops First Nanodrug Combination for Glioma - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Pharmaco-Kinesis Corporation Develops First Nanodrug Combination for Glioma



Pharmaco-Kinesis Corporation (PKC) announced that it is developing the first nanodrug combination of Merck’s temozolomide and Celgene’s thalidomide (in a 50:50 ratio) for the treatment of gliomas and other cancers. PKC will collaborate with the University of California, San Diego’s department of nano-engineering at the Moores cancer centre to develop the nanodroplet formulation.

According to PKC, 2000 to 20000 molecules of each type of drug can be packaged in one nanodroplet. Preliminary studies have indicated that the ratio of these different drugs can be precisely controlled. PKC’s goal is to produce nanodroplets that have special affinities for cancer cells with enhanced efficacy in destroying such cells compared with conventional chemotherapy.

PKC has begun in vivo testing of the temozolomide–thalidomide nanodroplets. Preliminary findings show that the combination is significantly more effective than the current commercially available formulations of these drugs that are being used in the clinic.

It is thought that direct local delivery is necessary to achieve the potentially high efficacy of the nanodrugs. PKC is developing a microminiaturized metronomic biofeedback pump nano (MBPn) version, a fully implantable infusion pump that enables programmable, metronomic, local delivery and sampling via a multichannel catheter that has the potential to avoid elimination by the liver. The company hopes that the MBPn will enhance anticancer activity of the drugs at the target site while reducing adverse effects on healthy cells.

"We are conducting ongoing development and testing in order to prove the efficacy of delivering proprietary nanodroplet formulations of anticancer medications using our MBP," said Frank Adell, CEO of PKC in a press statement. "If these tests are successful, we believe PKC will produce a major advance in treating gliomas and potentially other types of cancer as well."

ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
27%
Attracting a skilled workforce
27%
Obtaining/maintaining adequate financing
14%
Regulatory compliance
32%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns

Click here