High viscosity grade Nisso HPC-H (hydroxypropyl cellulose) offers advantages as a controlled release polymer when compared to HPMC in a sustained release matrix tablet application. In a direct compression application, HPC-H (fine powder type) sustains drug release more effectively than HPMC in the case of equivalent viscosity of the two polymers. Further, HPC-H has equivalent control release performance to HPMC 100000 while HPC-H has much lower viscosity, and this result is found when the tablet is prepared using either direct compression or wet granulation method.

Fig. 1: Effect of CR material (HPC vs HPMC, direct compression method)

Effect of CR Material (DC Method) is as shown in Fig 1. In the case of DC method, HPC-H-FP sustained drug release more than HPMC 4000, and showed equivalent release control performance to HPMC 100000 while its viscosity was much lower.

Fig 2: Effect of CR Material (HPC vs. HPMC, wet granulation method)

Effect of CR Polymer (WG Method) is as shown in Fig. 2. In the case of WG method, much difference was not seen in comparison of drug release from tablet prepared by HPC-H and HPC-H-FP. Also, Both HPC-H and HPC-H-FP showed equivalent release control performance to HPMC 100000. Drug release from tablet prepared by HPMC 4000 was much faster than the others.

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Catherine Cote
c.cote@nissoamerica.com
Nisso America Inc.
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Nisso Chemical Europe GmbH
Naoki Kuwada
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+49-(0)-211-1306686-0