Executives at major pharmaceutical companies are in the midst of an extended effort to drastically reduce costs in the face
of dramatic revenue losses. Staff reductions and facility closings have grabbed the headlines, with sales forces and obsolete
manufacturing operations taking the brunt of restructuring initiatives. Only the effort to rebuild new product pipelines through
in-licensing and acquisitions has garnered so much industry attention in recent years.
A major element of cost-reduction strategies has been increased sourcing from Asian countries, especially India and China.
The appeal, of course, has been the perception that those countries offer abundant scientific talent and investment capital
at much lower prices than equivalent human resources in North America and Western Europe. The major beneficiaries thus far
have been contract research organizatons (CROs) providing labor-intensive drug discovery services and chemical manufacturers
producing low-value intermediates and generic active pharmaceutical ingredients (APIs). Increasingly, however, higher-value
activities are migrating offshore, especially in the areas of clinical research, data management, and custom chemical manufacturing.
There are strong indications, however, that the terms of trade are becoming less favorable for the emerging Asian economies.
Resource prices are rising rapidly across a number of fronts.
Overall labor rate inflation is hovering around 10% annually in India and China, and rates in the pharmaceutical sector appear
to be growing even more rapidly. In India, while equipment operator wages remain less than 50% of equivalent labor rates in
developed economies, salaries for degreed pharmaceutical professionals in such areas as quality assurance and analytical chemistry
reportedly are now equal to those paid in the United States. In China, the heavy dependence on scientists returning from the
US and Europe is raising the price of senior scientific knowhow. Further, the New York Times recently reported that the Chinese government is pressuring major employers to allow employees to join the state-approved
labor union, which is pushing for better salaries, benefits, and working conditions.
The avoidance of environmental standards and regulations, which can help lower costs, has long been a dirty secret of outsourcing
to India and China. However, the Chinese government appears to be cracking down on major water and air polluters. Word throughout
industry is that many companies forced to shut down for the Beijing Olympics may not be allowed to reopen. Chemical firms'
pollution mitigation efforts are raising costs, and the reduced number of vendors may be raising prices.
Rising energy costs and constraints on shipping infrastructure are driving up shipping costs dramatically. According to
a report from CIBC World Markets, cited by McKinsey & Company in an August report on the global supply chain, shipping costs
from Asia have nearly quadrupled. Where shipping costs from China once added 3% to the cost of a product ex-factory, they
now add 11%, according to CIBC.
Naturally, the concerns over product quality from China in the past year have increased the amount of supply-chain due diligence
by pharmaceutical companies. Companies are realizing they must audit not only their immediate source of supply, but also the
companies farther back in the supply chain that are providing the raw materials to their suppliers. Additional audits are
raising the cost of sourcing from emerging markets, especially for companies that don't have sourcing infrastructure established
in those regions.
The net result of these changing resource price dynamics is that the resource price advantage of outsourcing to emerging markets
(at least to India and China) is eroding rapidly. Major pharmaceutical companies will continue to seek offshore sourcing opportunities,
partly because they are committed to emerging markets for top-line growth, and partly because they are slow to realize that
emerging markets no longer provide automatic cost savings. But as Lonza's CEO noted in his 2008 mid-year financial review,
the "club" of offshore sourcing that major pharmaceutical companies have used to get better pricing from suppliers is much
"softer" than it was a year ago.