Fred Fleitz,
senior manager, process R&D,
Cambridge Major Laboratories

Roger McDonald,
director, business development,
Cambridge Major Laboratories

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Patricia Van Arnum, senior editor of Pharmaceutical Technology, speaks with Fred Fleitz, senior manager, process R&D with Cambridge Major Laboratories, and Roger McDonald, director of business development with Cambridge Major Laboratories, on recent project work in optimizing several API syntheses. Fleitz discusses the approach taken in a condensation reaction between a naphthoquinone derivative and a substituted methyl vinyl ketone. McDonald discusses the optimization of a synthetic route for a complex natural product analogue. In another project, he discusses an approach taken to maintain the desired enantioselectivity of a molecule containing a chiral cyclopropane moiety during scale-up (Posted November 2011).