University Research Centers Transfer Continuous Manufacturing Technology to Industry - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

University Research Centers Transfer Continuous Manufacturing Technology to Industry
Engineering groups at Rutgers and MIT constructed solid-dosage continuous manufacturing lines and transferred the technology to pharmaceutical industry partners.

Equipment and Processing Report

University Research Centers Transfer Continuous Manufacturing Technology to the Pharmaceutical Industry

Continuous solid-dosage manufacturing that uses quality by design (QbD) for process set-up and process analytical technology (PAT) for continuous, real-time process control is a vision that is starting to become a reality. In the past year, research at university-based consortiums has been transferred to the pharmaceutical industry.

Researchers at Rutgers, the State University of New Jersey, in the Engineering Research Center for Structured Organic Particulate Systems (C-SOPS), successfully connected traditional unit operations to form a continuous direct compaction tableting process. C-SOPS, based on the Rutgers University campus and in partnership with Purdue University, The New Jersey Institute of Technology, and The University of Puerto Rico at Mayagüez, brings together a cross-disciplinary group of engineers, scientists, and industry leaders from academia, pharmaceutical manufacturers, and equipment manufacturers. C-SOPS has been investigating continuous manufacturing concepts since 2006 and has worked on both the fundamental science and commercialization of advanced pharmaceutical manufacturing. In 2012, C-SOPS collaborated with Janssen to develop a direct compaction line using continuous manufacturing principles. The continuous direct-compaction line replaces the traditional multistage batch process by integrating feeders, mills, blenders, and a tablet press into a single continuous process. C-SOPS researchers built a full-scale production line at Rutgers to test concepts and define a design space. Janssen is now constructing a line based on that design, which is hoped to be operational in 2014.

In developing the line, C-SOPS researchers defined parameters and performed design-space experiments to evaluate the effect of parameter changes. “Because the process is continuous, we were able to measure parameter-change effects in nearly real-time; we performed a full set of design experiments with dozens of conditions, in hours rather than days to weeks, and used a fraction of the API needed for batch processing,” explains Douglas Hausner, associate director for industrial relations and business development at C-SOPS.

A major challenge in developing continuous manufacturing is process control. “Control systems must be integrated with PAT using closed loop control and process management in order to fully implement QbD and completely control the system,” says Hausner. C-SOPS continues to work on process control integration within its production-scale Continuous Pharmaceutical Advanced Manufacturing Laboratory (CpAML).  At this facility, process-control hardware and software from various vendors are used with existing and emerging PAT in a production-scale pharmaceutical manufacturing facility. The environment allows research to be performed in an industrially realistic environment.

The Novartis–MIT Center for Continuous Manufacturing (CCM), based at the Massachusetts Institute of Technology (MIT), used a different approach to develop an API-to-coated tablet continuous manufacturing prototype. The Novartis–MIT CCM started the beginning of a 10-year partnership in late 2007 and completed its prototype, end-to-end continuous manufacturing line, which begins with forming the API and ends in coated tablets, in late 2011. The system was put together entirely from scratch and is completely new to drug manufacturing. In 2012, CCM completed its work of fully integrating a control system that automates the process as a whole by using mathematical models.  CCM researchers also published work in continuous reactive crystallization, which is integrated directly into the end-to-end process (1). MIT researchers are now focused on translating various technologies for transfer to Novartis, says Bernhardt Trout, director of the center and chemical engineering professor at MIT. Novartis has set up its own unit to implement continuous manufacturing on the pilot and ultimately to full-production scales and is planning to implement continuous manufacturing technologies across its entire portfolio, once testing at the upcoming pilot plant is successful.


  1. S.Y. Wong, et al., Cryst. Growth Des. 12 (11) 5701-5707 (2012).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Equipment and Processing Report,
Click here