Solubilizers play an important role in dissolving poorly soluble molecules. As the number of poorly soluble lipophilic and/or
hydrophobic molecules increases—whether as "brick dusts" or waxy substances—the industry is struggling to identify the appropriate
lipophilic excipients (surfactants, solubilizers, solvents or polymers) that can be used to develop such poorly soluble formulations
into solid dosages and other forms of pharmaceutical products. Furthermore, the complexity of such formulations is increasing
and often two or more solubilizers and/or cosolvents are required to develop stable and efficacious formulations with enhanced
Table I: Kolliphor® grades.
As pharmaceutical manufacturers develop generic and new molecules that require high-quality, functional excipients, they seek
support from excipient manufacturers. Indeed, the pharmaceutical industry relies on excipient manufacturers to design and
produce excipients that are appropriate to the envisaged dosage form and API. This is a complex undertaking made all the more
difficult because of the number of different names that manufacturers use for their excipients. However, several excipient
manufacturers are now streamlining the structure, nomenclature and functionality of their excipients, including solubilizers.
Table II: Kollisov® grades.
Such rebranding has been used in other industries to reduce complexity and to promote products on the merits of their performances
and qualities, ideally without undermining the old brands. This is now occurring among excipient manufacturers, particularly
those that carry lipophilic excipients, including BASF, as well as other companies. Many companies have used branding and
rebranding to either introduce new products or reintroduce an old product under a single 'prefix' to simplify identification.
In the case of BASF, Cremophor®, Solutol®, Lutrol® and other solubilizers will become part of the Kolliphor® brand family.
Table III: Kolliwax® grades.
The basis for rebranding with the same prefix is to identify molecules by structures, functions and the applications of choice;
enable the company's brand products to be recognized; and to differentiate pharmaceutical excipients from other grades. Rebranding
is a tedious and time-consuming process, and in some instances adds complexity if the functionality of the molecule is not
Table IV: Kollicream® grades.
Here, we provide a synopsis of how we have undertaken the process of rebranding our solubilizers for pharmaceutical applications.
With a few exceptions, we have tried to preserve some of the characters from the old product brand name to avoid confusion
and to allow scientists to easily recognize them. The surfactants and solubilizers, as well as related products, have been
categorized under four umbrella rebranding subgroups:
Kolliphor: For amphiphilic substances such as ionic and non-ionic surfactants, solubilizers and emulsifying agents, as shown in Table
Kollisolv: For solvents such as mediumchain triglycerides, propylene glycol, liquid polyethylene glycols and liquid poloxamers, as shown
in Table II.
Kolliwax: This name was coined to represent consistency factors, such as those in fatty acids, alcohols and glycerides, as shown in
Kollicream: The name was chosen to represent emollients such as fatty acid esters and special fatty alcohols, as shown in Table IV.