Editors' Picks of Pharmaceutical Science & Technology Innovations
To ensure that a tableting process will be predictable, active ingredients and excipients in powder form must undergo granulation.
This process results in granules, which comprise several particles each, and helps personnel produce tablets within the desired
specifications. This month's products aid the granulation process in various ways. A particle-size analyzer from Malvern Instruments
helps streamline particle measurement. Whitehouse Scientific's image analyzer provides powder characterization. Bosch's extrusion
line helps to form tablets accurately.
Particle-size analyzer facilitates dry-powder measurement
Malvern Instruments's Mastersizer 3000 particle-size analyzer is designed to extend dry measurements to a wide range of sample
types. It provides a 10-KHz data-acquisition rate, and all parameters for dry-powder measurement (i.e., sample feed rate,
dispersion pressure, and system cleaning) are controlled through the software by its SOP interface. Its real-time feedback
capability helps streamline method development and routine measurement.
The analyzer's Aero S dry-powder disperser enables users to measure materials from 0.01 to 3500 Ám. It disperses dry samples
by accelerating particles through a venturi mechanism, using compressed air at a user-defined pressure. The particles then
pass through the Mastersizer 3000's laser for measurement and are collected using a vacuum source. The sample feed rate through
the Aero S is closely controlled using a vibrating feeder, which maintains a suitable sample concentration for laser measurement.
It is fitted with an interchangeable sample tray that can be configured to ensure the measurement of enough material to quantify
the entire size distribution reproducibly.
Mastersizer 3000 Malvern Instruments www.malvern.com
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Image analyzer features particle characterization
The ShapeSizer image analyzer from Whitehouse Scientific can characterize particles in the size range of 1–5000 Ám. The analyzer
integrates a charge-coupled device camera with its software system, which is designed to provide a cost-effective solution
for a variety of industrial particulate applications where size and shape are important parameters.
Some key features of the ShapeSizer include automatic cluster recognition and elimination, a particle-separation and editing
facility, and a sieve calibration option. In addition, it contains a Miles-Lantuejoul option to maximize its field of view
without eliminating particles.
ShapeSizer image analyzer Whitehouse Scientific www.whitehousescientific.com
Extrusion and calendering line forms tablets accurately
Bosch Packaging Technology's integrated melt-extrusion and calendering line features a continuous production process for pharmaceutical
substances, and meets all GMP standards. Its modular structure enables manufacturers to customize extrusion and forming equipment.
Its capabilities feature direct shaping of pills or oblong shapes, in addition to pelletizing with its granulation-head technology.
The products can be used for customized scale-ups and are designed for contained or noncontained environments.
Melt-extrusion and calendering line Bosch Packaging Technology www.bosch.com
The line includes the Pharma Extruder WCF 0040PH, which continually processes the substrate with active ingredients through
the melting, mixing, kneading, aerating, tempering, and forming stages. Also included is the Pharma Calender BPK 0050, which
is designed to ensure accurate forming of tablets by using dual rollers with forming cavities.