Insufficient Product Yield - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Insufficient Product Yield

Equipment and Processing Report

Untitled Document

This issue marks the introduction of Equipment & Processing Report’s new “Troubleshooting” column. When a process does not produce the expected results, or when a piece of equipment behaves strangely, even experienced personnel sometimes may be at a loss to understand the reason why. This column will be a forum to discuss production problems. Readers will submit anonymous questions, which equipment vendors and industry professionals will attempt to answer. In this way, the column may help promote greater understanding of the industry's products and processes.

Q: Our dry-powdered product is not meeting a critical final-quality specification related to the particle-size distribution. We use a volumetric dry-material feeder and jet mill to create the finished product. When we charge the feeder hopper with a batch of material, the resulting particle-size distribution changes from the beginning of the run to the end of the run. Maybe the load in the mill (i.e., the feed rate through the system) drops off because the material is sensitive to head load and we have no feedback control on the material feed rate. Why doesn’t our particle-size distribution stay consistent throughout the run? How can we meet our final-quality specification?

A: Try performing additional testing in the laboratory using a gravimetric feeder, which has a scale that is monitored by a controller. The controller uses the data from the scale to calculate a feed rate and provide a feedback control loop to maintain a set feed rate.

It is indeed likely that your material’s flow properties are sensitive to head load, and without the feedback control loop, the feed rate drops off as the feed hopper empties. The control loop in the gravimetric feeder should be able to increase the speed of the auger. This increased auger speed could compensate for the change in material flow that results from the change in head load. Also, the increased auger speed could help maintain the feed rate for more than 95% of the hopper capacity. Using a gravimetric feeder that provides a feedback control loop could increase your product quality and yield.

—Chad Lorensen, business-development manager at Schenck AccuRate (Whitewater, WI)

 

If you have a problem with your equipment or process, an industry expert may have the solution. Please send your question to Erik Greb, editor of Equipment and Processing Report, and we may be able to provide an answer in a future issue. All questions will remain anonymous.

ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What is the single greatest threat to maintaining manufacturing processes at your facility?
Quality issues
Facility/environment problems
Process development problems
Production equipment downtime
Raw material supply problems
Regulatory restrictions
Business decisions to limit production
Quality issues
67%
Facility/environment problems
0%
Process development problems
0%
Production equipment downtime
0%
Raw material supply problems
33%
Regulatory restrictions
0%
Business decisions to limit production
0%
View Results
UPCOMING CONFERENCES

Programs for Investigational and Pre-Launch Drugs
Philadelphia, PA
July 17-18, 2013
Request Brochure

Strategic Pipeline Planning & Portfolio Valuation
Philadelphia, PA
August 13-14, 2013
Request Brochure

MES 2013 - Forum on Manufacturing Execution Systems
Philadelphia, PA
August 14-15, 2013
Request Brochure

Mobile Innovation for the Life Sciences Industry
Philadelphia, PA
August 20-21, 2013
Request Brochure

See All Conferences >>

Eric Langer Outsourcing Outlook Eric LangerOutsourcing's Modest Role as a Cost-Containment Strategy
Patricia Van Arnum Ingredients Insider Patricia Van ArnumIntellectual Property Battles in Solid-State Chemistry
Nathan Jessop Industry Insider Nathan Jessop Campaign Against Counterfeit Drugs Continues
Lynn Torbeck Statistical Solutions Lynn D. TorbeckCompositing Samples and the Risk to Product Quality
 More
Patent Settlements Become More Risky
Praise and Perils for Biotechnology Patent Policy
Risk-Mitigation Strategies in Drug Manufacturing for Emerging Markets
Quality Focus: Ensuring Raw Material Transparency
Advertising of Prescription Drugs  Keeping it Honest and Balanced
Source: Equipment and Processing Report,
Click here