Working with Tubing for Peristaltic Pumps - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Working with Tubing for Peristaltic Pumps
Thermoplastic elastomer tubing can be used for an entire line, including through the peristaltic pump.

Equipment and Processing Report

Untitled Document

Q. My application involves a peristaltic pump with silicone tubing running through it and a different, heat-sealable tubing material before and after the pump section. Recently, an operator installed the wrong section of tubing in a pump, resulting in lost API, equipment replacement, and hours of extra work. How can we avoid this kind of mix-up in the future?

A. One solution is to label different tubing sections for their intended use. Another approach is to use one tubing material, namely a thermoplastic elastomer (TPE), for the entire line. TPE is often used before and after the pump section where sealability is needed. TPE properties vary depending on the formulation and the process used to make the polymer, and in the past some formulations could not be used inside the pump. Today, however, there are versions of TPE that work very well in peristaltic pumps and can be used for the entire line. 

A possible concern is using steam sterilization with TPE because steam tends to deform tubing.  Some steam cycles can be used as long as they have a lower temperature and time exposure cycle and care is taken in positioning the tubing in the autoclave. A user who intends to sterilize with steam should validate their sterilization cycle with the intended use of a TPE tubing. Gamma radiation sterilization poses no problems with either silicone or TPE.

Using a single tubing eliminates fitting connections and tie wraps, along with their possible leaks and entrapment issues. Having a single material also simplifies the overall design, reduces inventory expenses, shortens assembly time and labor, and eliminates the possibility of installing the wrong tubing section in the pump.

—John Stover, product technical director, New Age Industries.

If you have a problem with your equipment or process, an industry expert may have the solution. Please send your question to Jennifer Markarian, editor of Equipment and Processing Report, and we may be able to provide an answer in a future issue. All questions will remain anonymous.

 

ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
26%
Attracting a skilled workforce
29%
Obtaining/maintaining adequate financing
14%
Regulatory compliance
31%
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Report: Pfizer Makes $101 Billion Offer to AstraZeneca
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Source: Equipment and Processing Report,
Click here