The Effect of Shear Mixing on the Blending of Cohesive Lubricants and Drugs - Pharmaceutical Technology

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The Effect of Shear Mixing on the Blending of Cohesive Lubricants and Drugs
Manufacturers must find the appropriate amount of shear mixing to attain the desired drug properties.


Pharmaceutical Technology


Marcos Llusá is a doctoral student in the department of chemical and biochemical engineering at Rutgers University, tel. 732.445.2588,
and Fernando Muzzio, PhD, is a professor and the director of the NJ Particle Processing Research Center at Rutgers University, tel. 732.445.3357,
Dr. Muzzio also is a member of Pharmaceutical Technology's editorial advisory board.

To whom all correspondence should be addressed.

References

1. G. Ragnarsson, A.W. Hölzer, and J. Sjögren, "The Influence of Mixing Time and Colloidal Silica on the Lubricating Properties of Magnesium Stearate," Int. J. Pharm. 3 (2–3), 127–131 (1979).

2. J.G. Van der Watt and M.M. de Villiers, "The Effect of V-Mixer Scale-Up on the Mixing of Magnesium Stearate with Direct Compression Microcrystalline Cellulose," Eur. J. Pharm. Biopharm. 43 (1), 91–94 (1997).

3. C.E. Bos, H. Vromans, and C.F. Lerk, "Lubricant Sensitivity in Relation to Bulk Density for Granulations Based on Starch or Cellulose," Int. J. Pharm. 67 (1), 39–49 (1991).

4. R.P. Poska, T.R. Hill, and J.W. van Schaik, "The Use of Statistical Indices to Gauge the Mixing Efficiency of a Conical Screening Mill," Pharm. Res. 10 (8), 1248–1251 (1993).

5. Y.L. Ding et al., "Scaling Relationships for Rotating Drums," Chem. Eng. Sci. 56 (12), 3737–3750 (2001).

6. C. Clump, "Mixing of Solids" in Mixing, Theory and Practice, Volume II, V. Uhl and J. Gray, Eds. (Academic Press, San Diego, CA, 1967), p. 284

7. L.P. Kadanoff et al., "Scaling and Universality in Avalanches," Phys. Rev. A: At., Mol., Opt., Phys. 39 (12), 6524–6537 (1989).

8. N. Sepúlveda, G. Krstulovic, and S. Rica, "Scaling Laws in Granular Continuous Avalanches in a Rotating Drum," Physica A 356 (1), 178–183 (2005).

9. H.E. Stanley et al., "Scaling and Universality in Animate and Inanimate Systems," Physica A 231 (1–3), 20–48 (1996).

10. G. Weir, D. Krouse, and P. McGavin, "The Maximum Thickness of Upper-Shear Layers of Granular Materials in Rotating Cylinders," Chem. Eng. Sci. 60 (7), 2027–2035 (2005).

11. A. Alexander et al., "Characterization of the Performance of Bin Blenders," Pharm. Technol. 28 (9), 54–74 (2004).


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