Solid-State Characterization and Dissolution Properties of Lovastatin Hydroxypropyl-β-Cyclodextrin Inclusion Complex - Pharmaceutical Technology

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Solid-State Characterization and Dissolution Properties of Lovastatin Hydroxypropyl-β-Cyclodextrin Inclusion Complex
The objectives of this study were to prepare and characterize inclusion complexes of lovastatin with hydroxypropyl-β-cyclodextrin (HPβ-CD) and to study the effect of the complexes on the dissolution rate of lovastatin (LVS). The findings suggest that LVS's poor dissolution profile can be overcome by preparing its inclusion complex with HPβ-CD.

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11. J. Peeters et al., "Characterization of the Interaction of 2-Hydroxypropyl-Betacyclodextrin with Itraconazole at pH 2, 4, and 7," J. Pharm. Sci . 91 (66), 1414–1422 (2002).

12. F. J. Veiga et al., "Molecular Modeling and 1H-NMR: Ultimate Tools for the Investigation of Tolbutamide: β-Cyclodextrin and Tolbutamide: Hydroxypropyl-β-Cyclodextrin Complexes," Chem. Pharm. Bull. (Tokyo). 49 (10), 1251–1256 (2001).

13. J. Szejtli, "Medicinal Applications of Cyclodextrins," Med. Res. Rev. 14 (3), 353–386 (1994).

14. J.W. Moore and H. Flanner, "Mathematical Comparison of Dissolution Profiles," Pharm. Technol. 20 (6), 64–74 (1996).

15. US Food and Drug Administration, Guidance for Industry SUPAC-MR: Modified Release Solid Oral Dosage Forms Scale-Up and Postapproval Changes: Chemistry, Manufacturing, and Controls; In Vitro Dissolution Testing and In Vivo Bioequivalence Documentation (FDA, Rockville, MD, 1997).

16. Human Medicines Evaluation Unit, European Agency for the Evaluation of Medicinal Products (EMEA), Notes for Guidance on Quality of Modified-Release Products; A Oral Dosage Forms; B Transdermal Dosage Forms, Section 1 (Quality) (EMEA, London, UK, 1999).

17. C. Reppas and E. Nicolaides, "Analysis of Drug Dissolution Data," in Oral Drug Absorption Prediction and Assessment, J.B. Dressman and H. Lennernäs, Eds. (Marcel Dekker, Inc., New York, NY, 2000), pp. 229–254.

18. M.L. Vueba et al.,"Influence of Cellulose Ether Polymers on Ketoprofen Release from Hydrophilic Matrix Tablets," Eur. J. Pharm. and Biopharm. 58 (1), 51–59 (2004).

19. T. Higuchi and K. Connors, "Phase Solubility Techniques," in Advances in Analytical Chemistry and Instrumention, C.N. Reilly, Ed. (John Wiley, New York, NY, 1965) 4, 117–212.

20. S. Mattsson and C. Nyström, "The Use of Mercury Porosimetry in Assessing the Effect of Different Binders on the Pore Structure and Bonding Properties of Tablets," Eur. J. Pharm. Biopharm. 52 (2), 237–247 (2001).

21. K. Kawakita, "Compression of Powder," Kagaku . 26, 149–150 (1956).

22. R.L. Carr, "Evaluating Flow Properties of Solids," Chem. Eng. 72 (2), 163–168 (1965).

23. D. Peri et al.,"Inclusion Complexes of Tolnaftate with β-Cyclodextrin and Hydroxy-β-Cyclodextrin," Drug Dev. Ind. Pharm. 20 (88), 1401–1410 (1994).

24. J.J.T. Labenderia et al., "Glibornuride-β-Cyclodextrin Inclusion Complexes: Preparation, Structural Characterization, and In Vitro Dissolution Behavior," Eur. J. Pharm. and Biopharm. 39 (6), 255–259 (1993).


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