Copolymerized PEGlyated Acrylate Hydrogels for Delivery of Dicolofenac Sodium - Pharmaceutical Technology

Latest Issue

Latest Issue
PharmTech Europe

Copolymerized PEGlyated Acrylate Hydrogels for Delivery of Dicolofenac Sodium
Hydrogels are biocompatible drug delivery systems by which the physical properties can be controlled by the cross-linking density. Hydrogels were prepared by copolymerization of acrylic acid monomers in the presence of poly(ethylene glycol)(PEG) to form polyethylene diacrylate (PEDGA). Various molecular weights of PEGs were used for the synthesis of PEGDA to study the effect of molecular weight of PEG on the properties of hydrogels. These hydrogels were further characterized for free water, swelling..

Pharmaceutical Technology

8. N.A. Peppas et al., "Hydrogels in Pharmaceutical Formulations," Eur. J. Pharm. Biopharm. 50 (1), 27–46 (2000).

9. V.R. Patel and M.M. Amiji, "Preparation and Characterization of Freeze-Dried Chitosan Poly(ethylene oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach," Pharm. Res. 13 (44), 588–593 (1996).

10. V.R. Sinha and L. Khosla, "Bioabsorbable Polymers for Implantable Therapeutic Systems." Drug Dev. Ind. Pharm. 24 (12), 1129–1138 (1998).

11. J.Y. Fang et al., "Transdermal Iontophoresis of Sodium Nonivamide Acetate IV Effect of Polymer Formulations," Int. J. Pharm.173 (1–2), 127–140 (1998).

12. J.Y. Fang et al.,"Evaluation of Transdermal Iontophoresis of Enoxacin from Polymer Formulations: In Vitro Permeation and In vivo Microdialysis Using Wister Rat as an Animal Model," Int. J. Pharm. 180 (2), 137–149 (1999).

13. O.M. Conaghey, J. Currish, and O.I. Corrigan, "Iontophoretically Assisted In Vitro Membrane Transport of Nicotine from a Hydrogel Containing Ion Exchange Resins," Int. J. Pharm. 170 (2), 225–237 (1998).

14. A. Kikuchi and T. Okano, "Pulsatile Drug Release Control Using Hydrogels," Adv. Drug Del. Rev. 54 (1), 53–77 (2002).

15. T.A. Holland, Y. Tabata, and A.G. Mikos, "Dual Growth Factor Delivery from Degradable Oligo(Poly(ethylene glycol) Fumarate) Hydrogel Scaffolds for Cartilage Tissue Engineering," J. Controlled Release 101 (1–3), 111–125 (2005).

16. S.V. Vinogradov, T.K. Bronich, and A.V. Kabanov, "Nanosized Cationic Hydrogels for Drug Delivery: Preparation, Properties and Interactions with Cells," Adv. Drug Del. Rev. 54 (1), 135–147 (2002).

17. L.F. Wang, S.S. Shen, and S.C. Lu, "Synthesis and Characterization of Chondroitin Sulfate-Methacrylate Hydrogels," Carbohydrate Polymers 52 (4), 389–396 (2003).

18. G.V Mooteo, L. Vervoort, and R. Kinget, "Characterization of Methacrylated Inulin Hydrogels Designed for Colon Targeting: In Vitro Release of BSA," Pharm. Res. 20 (2), 303–307 (2003).

19. S.N. Park et al., "Biological Characterization of EDC Crosslinked Collagen-Hyaluronic Acid Matrix in Dermal Tissue Restoration," Biomaterials 24 (9), 1631–1641 (2003).

20. S. Cai et al., "Injectable Glycosaminoglycan Hydrogels for Controlled Release of Human Basic Fibroblast Growth Factor," Biomaterials 26 (30), 6054–6067 (2005).

21. X. Lou et al., "Morphological and Topographic Effects on Calcification Tendency of pHEMA Hydrogels." Biomaterials 26 (29), 5808–5817 (2005).


blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
| Weekly

Which of the following business challenge poses the greatest threat to your company?
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
Building a sustainable pipeline of products
Attracting a skilled workforce
Obtaining/maintaining adequate financing
Regulatory compliance
View Results
Eric Langer Outsourcing Outlook Eric LangerBiopharma Outsourcing Activities Update
Cynthia Challener, PhD Ingredients Insider Cynthia Challener, PhDAppropriate Process Design Critical for Commercial Manufacture of Highly Potent APIs
Jill Wechsler Regulatory Watch Jill Wechsler FDA and Manufacturers Seek a More Secure Drug Supply Chain
Sean Milmo European Regulatory WatcchSean MilmoQuality by Design?Bridging the Gap between Concept and Implementation
Medicare Payment Data Raises Questions About Drug Costs
FDA Wants You!
A New Strategy to Tackle Antibiotic Resistance
Drug-Diagnostic Development Stymied by Payer Concerns
Obama Administration Halts Attack on Medicare Drug Plans
Source: Pharmaceutical Technology,
Click here