Review of Current Issues in Pharmaceutical Excipients - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Review of Current Issues in Pharmaceutical Excipients
Excipients facilitate formulation design and perform a wide range of functions to obtain desired properties for the finished drug product. The article reviews excipient development and functionality of these materials, including their importance in formulation design, potential processing challenges directly related to excipients, and therapeutic benefits.


Pharmaceutical Technology


16. P.J. Weller, "Ceratonia," in Handbook of Pharmaceutical Excipients, R.C. Rowe, P.J. Sheskey, and P.J. Weller, Eds. (Pharmaceutical Press and American Pharmaceutical Association, Chicago, IL, 2003), pp. 123–124.

17. B. Wittgren, M. Stefansson, and B. Porsch, "Interactions between Sodium Dodecyl Sulphate and Non-Ionic Cellulose Derivatives Studies by Size Exclusion Chromatography with Online Multiangle Light Scattering and Refractometric Detection," J. Chromatogr. A. 1082 (2), 166–175 (2005).

18. J.A. Menendez et al., "A Genomic Explanation Connecting Mediterranean Diet, Olive Oil, and Cancer: Oleic Acid, the Main Monounsaturated Fatty Acid of Olive Oil, Induces Formation of Inhibitory PEA3 Transcription Factor-PEA3 DNA Binding Site Complexes at Her-2/neu (erbB-2) Oncogene Promoter in Breast, Ovarian, and Stomach Cancer Cells," Eur. J. Cancer (Jan. 4, 2006).

19. J.A. Menendez et al., "Effect of Gamma-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene," J. Natl. Cancer Inst. 97 (21), 1611–1615 (2005).

20. J.A. Menendez, R. Lupu, and R. Colomer, "Targeting Fatty Acid Synthase: Potential for Therapeutic Intervention in Her-2/neu-OverExpressing Breast Cancer," Drug News Perspect. Jul.-Aug, 18 (6), 375-85 (2005)

21. M. Uhari, T. Kontiokari, and M. Niemela, "A Novel Use of Xylitol Sugar in Preventing Acute Otitis Media," Pediatrics 102 (4), 879–884 (1998).

22. "FDA Issues Glucose Meter Safety Warning," DOC News 3 (1), 7, http://docnews.diabetesjournals.org/cgi/content/full/3/1/7, accessed April 1, 2007.

23. A.M. Cattelan et al., "Use of Polylactic Acid Implants to Correct Facial Lipoatrophy in Human Immunodeficiency Virus 1-Positive Individuals Receiving Combination Antiretroviral Therapy," Arch Dermatol. 142 (3), 362–364 (2006).

24. T. Gyotoku, L. Aurelian, and A.R. Neurath, "Cellulose Acetate Phthalate (CAP): An 'Inactive' Pharmaceutical Excipient with Antiviral Activity in the Mouse Model of Genital Herpesvirus Infection," Antiviral Chem. Chemotherapy 10, 327–332 (1999).

25. http://www.aromatherapy.com/essentialoils.html.

26. http://www.ars.usda.gov/is/AR/archive/apr04/cinnam0404.html.

27. J. Morton, "Taking the Color of Medications Seriously," http://www.colormatters.com/body_pills.html, accessed April 1, 2007.

28. Capsugel List of Colorants for Oral Drugs, 11th ed. (Pfizer Inc. Capsugel Division, 2002).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here