Review of Current Issues in Pharmaceutical Excipients - Pharmaceutical Technology

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Review of Current Issues in Pharmaceutical Excipients
Excipients facilitate formulation design and perform a wide range of functions to obtain desired properties for the finished drug product. The article reviews excipient development and functionality of these materials, including their importance in formulation design, potential processing challenges directly related to excipients, and therapeutic benefits.


Pharmaceutical Technology


16. P.J. Weller, "Ceratonia," in Handbook of Pharmaceutical Excipients, R.C. Rowe, P.J. Sheskey, and P.J. Weller, Eds. (Pharmaceutical Press and American Pharmaceutical Association, Chicago, IL, 2003), pp. 123–124.

17. B. Wittgren, M. Stefansson, and B. Porsch, "Interactions between Sodium Dodecyl Sulphate and Non-Ionic Cellulose Derivatives Studies by Size Exclusion Chromatography with Online Multiangle Light Scattering and Refractometric Detection," J. Chromatogr. A. 1082 (2), 166–175 (2005).

18. J.A. Menendez et al., "A Genomic Explanation Connecting Mediterranean Diet, Olive Oil, and Cancer: Oleic Acid, the Main Monounsaturated Fatty Acid of Olive Oil, Induces Formation of Inhibitory PEA3 Transcription Factor-PEA3 DNA Binding Site Complexes at Her-2/neu (erbB-2) Oncogene Promoter in Breast, Ovarian, and Stomach Cancer Cells," Eur. J. Cancer (Jan. 4, 2006).

19. J.A. Menendez et al., "Effect of Gamma-Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene," J. Natl. Cancer Inst. 97 (21), 1611–1615 (2005).

20. J.A. Menendez, R. Lupu, and R. Colomer, "Targeting Fatty Acid Synthase: Potential for Therapeutic Intervention in Her-2/neu-OverExpressing Breast Cancer," Drug News Perspect. Jul.-Aug, 18 (6), 375-85 (2005)

21. M. Uhari, T. Kontiokari, and M. Niemela, "A Novel Use of Xylitol Sugar in Preventing Acute Otitis Media," Pediatrics 102 (4), 879–884 (1998).

22. "FDA Issues Glucose Meter Safety Warning," DOC News 3 (1), 7, http://docnews.diabetesjournals.org/cgi/content/full/3/1/7, accessed April 1, 2007.

23. A.M. Cattelan et al., "Use of Polylactic Acid Implants to Correct Facial Lipoatrophy in Human Immunodeficiency Virus 1-Positive Individuals Receiving Combination Antiretroviral Therapy," Arch Dermatol. 142 (3), 362–364 (2006).

24. T. Gyotoku, L. Aurelian, and A.R. Neurath, "Cellulose Acetate Phthalate (CAP): An 'Inactive' Pharmaceutical Excipient with Antiviral Activity in the Mouse Model of Genital Herpesvirus Infection," Antiviral Chem. Chemotherapy 10, 327–332 (1999).

25. http://www.aromatherapy.com/essentialoils.html.

26. http://www.ars.usda.gov/is/AR/archive/apr04/cinnam0404.html.

27. J. Morton, "Taking the Color of Medications Seriously," http://www.colormatters.com/body_pills.html, accessed April 1, 2007.

28. Capsugel List of Colorants for Oral Drugs, 11th ed. (Pfizer Inc. Capsugel Division, 2002).


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