Solubility, Polymorphism, Crystallinity, Crystal Habit, and Drying Scheme of (R, S)-(±)-Sodium Ibuprofen Dihydrate - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Solubility, Polymorphism, Crystallinity, Crystal Habit, and Drying Scheme of (R, S)-(±)-Sodium Ibuprofen Dihydrate
The racemic compound (R, S)-()-ibuprofen is a popular and well understood active pharmaceutical ingredient, but it has several disadvantageous formulation properties such as poor solubility, low melting point, and potential esterification with excipients containing an hydroxyl group. The authors investigate the use of an (R, S)-()-ibuprofen salt to evaluate these problems using various analytical methods to determine the polymorphism, crystallinity, and drying scheme.


Pharmaceutical Technology


17. R.A. Granberg and A.C. Rasmuson, "Solubility of Paracetamol in Binary and Ternary Mixtures of Water + Acetone + Toluene," J. Chem. Eng. Data 45 (3), 478–483 (2000).

18. L. Peterson et al., "Interactive High-Throughput Polymorphism Studies on Acetaminophen and An experimentally Derived Structure for Form III," J. Am. Chem. Soc. 124 (37), 10958–10959 (2002).

19. J.S. Drury, "Miscibility of Organic Solvent Pairs," Ind. Eng. Chem. 44 (11), 2744 (1952).

20. W.M. Jackson and J. S. Drury, "Miscibility of Organic Solvent Pairs," Ind. Eng. Chem. 51 (12), 1491–1493 (1959).

21. P. Bustamante, M.A. Pena, and J. Barra, "The Modified Extended Hansen Method to Determine Partial Solubility Parameters of Drugs Containing a Single Hydrogen Bonding Group and their Sodium Derivatives: Benzoic Acid/Na and Ibuprofen/Na," Int. J. Pharm. 194 (1), 117–124 (2000).

22. W.L. Archer, "Hansen Solubility Parameters for Selected Cellulose Ether Derivatives and Their Use in the Pharmaceutical Industry," Drug Dev. Ind. Pharm. 18 (5), 599–616 (1992).

23. L.R. Chen, and D.J W. Grant, "Extension of Clausius-Clapeyron Equation to Predict Hydrate Stability at Different Temperature," Pharm. Dev. Tech. 3 (4), 487–494 (1988).

24. G.G.Z. Zhang et al., "Racemic Species of Sodium Ibuprofen: Characterization and Polymorphic Relationships," J. Pharm. Sci. 92 (7), 1356–1366 (2003).

25. P.J. Haines, "Differential Thermal Analysis and Differential Scanning Calorimetry," in Thermal Methods of Analysis: Principles, Applications and Problems (Blackie Academic & Professional, New York, 1997), p.28.

26. J.M.E. Bunyan, N. Shankland, and D.B. Sheen, "Solvent Effects on the Morphology of Ibuprofen," AIChE Symp. Ser. 87 (284), 44–57 (1991).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
What role should the US government play in the current Ebola outbreak?
Finance development of drugs to treat/prevent disease.
Oversee medical treatment of patients in the US.
Provide treatment for patients globally.
All of the above.
No government involvement in patient treatment or drug development.
Finance development of drugs to treat/prevent disease.
23%
Oversee medical treatment of patients in the US.
14%
Provide treatment for patients globally.
7%
All of the above.
47%
No government involvement in patient treatment or drug development.
9%
Jim Miller Outsourcing Outlook Jim MillerOutside Looking In
Cynthia Challener, PhD Ingredients Insider Cynthia ChallenerAdvances in Large-Scale Heterocyclic Synthesis
Jill Wechsler Regulatory Watch Jill Wechsler New Era for Generic Drugs
Sean Milmo European Regulatory WatchSean MilmoTackling Drug Shortages
New Congress to Tackle Health Reform, Biomedical Innovation, Tax Policy
Combination Products Challenge Biopharma Manufacturers
Seven Steps to Solving Tabletting and Tooling ProblemsStep 1: Clean
Legislators Urge Added Incentives for Ebola Drug Development
FDA Reorganization to Promote Drug Quality
Source: Pharmaceutical Technology,
Click here