Solubility, Polymorphism, Crystallinity, Crystal Habit, and Drying Scheme of (R, S)-(±)-Sodium Ibuprofen Dihydrate - Pharmaceutical Technology

Latest Issue
PharmTech

Latest Issue
PharmTech Europe

Solubility, Polymorphism, Crystallinity, Crystal Habit, and Drying Scheme of (R, S)-(±)-Sodium Ibuprofen Dihydrate
The racemic compound (R, S)-(±)-ibuprofen is a popular and well understood active pharmaceutical ingredient, but it has several disadvantageous formulation properties such as poor solubility, low melting point, and potential esterification with excipients containing an hydroxyl group. The authors investigate the use of an (R, S)-(±)-ibuprofen salt to evaluate these problems using various analytical methods to determine the polymorphism, crystallinity, and drying scheme.


Pharmaceutical Technology


17. R.A. Granberg and A.C. Rasmuson, "Solubility of Paracetamol in Binary and Ternary Mixtures of Water + Acetone + Toluene," J. Chem. Eng. Data 45 (3), 478–483 (2000).

18. L. Peterson et al., "Interactive High-Throughput Polymorphism Studies on Acetaminophen and An experimentally Derived Structure for Form III," J. Am. Chem. Soc. 124 (37), 10958–10959 (2002).

19. J.S. Drury, "Miscibility of Organic Solvent Pairs," Ind. Eng. Chem. 44 (11), 2744 (1952).

20. W.M. Jackson and J. S. Drury, "Miscibility of Organic Solvent Pairs," Ind. Eng. Chem. 51 (12), 1491–1493 (1959).

21. P. Bustamante, M.A. Pena, and J. Barra, "The Modified Extended Hansen Method to Determine Partial Solubility Parameters of Drugs Containing a Single Hydrogen Bonding Group and their Sodium Derivatives: Benzoic Acid/Na and Ibuprofen/Na," Int. J. Pharm. 194 (1), 117–124 (2000).

22. W.L. Archer, "Hansen Solubility Parameters for Selected Cellulose Ether Derivatives and Their Use in the Pharmaceutical Industry," Drug Dev. Ind. Pharm. 18 (5), 599–616 (1992).

23. L.R. Chen, and D.J W. Grant, "Extension of Clausius-Clapeyron Equation to Predict Hydrate Stability at Different Temperature," Pharm. Dev. Tech. 3 (4), 487–494 (1988).

24. G.G.Z. Zhang et al., "Racemic Species of Sodium Ibuprofen: Characterization and Polymorphic Relationships," J. Pharm. Sci. 92 (7), 1356–1366 (2003).

25. P.J. Haines, "Differential Thermal Analysis and Differential Scanning Calorimetry," in Thermal Methods of Analysis: Principles, Applications and Problems (Blackie Academic & Professional, New York, 1997), p.28.

26. J.M.E. Bunyan, N. Shankland, and D.B. Sheen, "Solvent Effects on the Morphology of Ibuprofen," AIChE Symp. Ser. 87 (284), 44–57 (1991).


ADVERTISEMENT

blog comments powered by Disqus
LCGC E-mail Newsletters

Subscribe: Click to learn more about the newsletter
| Weekly
| Monthly
|Monthly
| Weekly

Survey
How does your company apply quality-by-design (QbD) principles to manufacturing processes?
To all processes for both new and legacy products
To all process for new products only
To select process for new products only
To select processes for both new and legacy products
Do not use QbD
To all processes for both new and legacy products
19%
To all process for new products only
14%
To select process for new products only
24%
To select processes for both new and legacy products
19%
Do not use QbD
24%
View Results
UPCOMING CONFERENCES

Programs for Investigational and Pre-Launch Drugs
Philadelphia, PA
July 17-18, 2013
Request Brochure

Strategic Pipeline Planning & Portfolio Valuation
Philadelphia, PA
August 13-14, 2013
Request Brochure

MES 2013 - Forum on Manufacturing Execution Systems
Philadelphia, PA
August 14-15, 2013
Request Brochure

Mobile Innovation for the Life Sciences Industry
Philadelphia, PA
August 20-21, 2013
Request Brochure

See All Conferences >>

Eric Langer Outsourcing Outlook Eric LangerOutsourcing's Modest Role as a Cost-Containment Strategy
Patricia Van Arnum Ingredients Insider Patricia Van ArnumIntellectual Property Battles in Solid-State Chemistry
Nathan Jessop Industry Insider Nathan Jessop Campaign Against Counterfeit Drugs Continues
Lynn Torbeck Statistical Solutions Lynn D. TorbeckCompositing Samples and the Risk to Product Quality
 More
Global Biosimilars Market to Reach $2.445 Billion in 2013
Adapting to Change
AstraZeneca and Exco InTouch Collaborate to Augment Current COPD Pathways
Overcoming the Challenges in Biopharmaceutical Stability Testing
PhRMA Dismayed by Special 301 Report
FindPharma Custom Search
Source: Pharmaceutical Technology,
Click here