Advancing Approaches in Detecting Polymorphism - Pharmaceutical Technology

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Advancing Approaches in Detecting Polymorphism
Identifying polymorphs is a crucial part of the drug-development process as researchers forward select methods to improve detection.


Pharmaceutical Technology


4. M. Haisa et al., "The Monoclinic Form of p-Hydroxyacetanilide," Acta Cryst. B32, 1283–1285 (1976).

5. A. Burger in Acta Pharm. Technol. 28 (1), 1–20 (1982).

6. P. DiMartino et al., " Preparation and Physical Characterization of Forms II and III of Paracetamol," J. Therm. Anal. 48 (3), 447–458 (1997).

7. G. Nichols and C.S. Frampton, "Physicochemical Characterization of the Orthorhombic Polymorph of Paracetamol Crystallized from Solution," J. Pharm. Sci. 87 (6), 684–693 (1998).

8. D Kovala-Demertzi, D. Mentzafos, and A. Terzis, "Metal Complexes of the Anti-inflammatory Drug Sodium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate (diclofenac sodium," Polyhedron 12 (11), 1361–1370 (1993).

9. C. Castellari and S. Ottani, "Two Monoclinic Forms of Diclofenac Acid," Acta Cryst. C53, 794–797 (1997).

10. N. Jaiboon et al., "New Orthorhombic Form of 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid (Diclofenac Acid)," Anal. Sci. 17, 1465–1466 (2001).

11. N. Muangsin et al., "Crystal Structure of a Unique Sodium Distorted Linkage in Diclofenac Sodium Pentahydrate," Anal. Sci. 18, 967–968 (2002).

12. P.J. Akins, "Dry Powder Inhalers: An Overview," Resp. Care 50 (10), 1314–1312 (2005).

13. A. Giordani et al., "New Crystalline and Stable form of Andolast," US Patent Application 20070149586, June 28, 2007.

14. A. Giordani et al.,"A New Crystalline and Stable Form of Andolast," EP Application 06112427.7, Apr. 10, 2006.

15. F. Makovec et al., "Derivatives of N-Phenylbenzamide with Anti-Ulcer and Anti-Allergy Activity and a Method for their Preparation, " WO 9009989 PCT, Sept. 7, 1990.

16. C.S. Frampton et al., "Combinatorial Screening System with X-ray Diffraction and Raman Spectroscopy," US Patent US 2006/0023837 A1, Feb. 2, 2006.

17. S.R. Byrn, "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations," Pharm. Res. 12, 945–954 (1995).

18. D. Xu and N. Redman-Furey, "Statistical Cluster Analysis of Pharmaceutical Solvents," Intl. J. of Pharm. 339 (1-2), 175–188 (2007).

19. J.M. Miller et al., "Identifying the Stable Polymorph Early in the Drug Discovery-Development Process," Pharm. Dev. Technol. 10 (2), 291–297 (2005).

20. S. Chen, I.A. Guzei, and L. Yu, "New Polymorphs of ROY and New Record for Coexisting Polymorphs of Solved Structures," J. Am. Chem. Soc. 127 (27), 9881–9885 (2005).


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